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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Concurrent Use of Aromatase Inhibitors and Radiotherapy Induces Echocardiographic Changes in Patients with Breast Cancer
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The Concurrent Use of Aromatase Inhibitors and Radiotherapy Induces Echocardiographic Changes in Patients with Breast Cancer

机译：芳香酶抑制剂和放疗的同时使用可诱发乳腺癌患者的超声心动图改变

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Aim: Adjuvant radiotherapy (RT) for left-sided breast cancer has a negative impact on cardiac health. The concurrent use of aromatase inhibitors (AIs) during RT was found to increase the anticancer efficacy of radiation in preclinical models. We evaluated whether the acute effects of RT on cardiac functions are augmented by the concurrent use of AIs. Patients and Methods: Sixty patients with early-stage left-sided breast cancer underwent a 2D echocardiography, electrocardiogram and cardiac biomarker measurements before and after adjuvant breast RT. Data were analyzed in two groups according to AI use. Results: We observed a significant (p<0.05) decrease in right ventricular systolic function during RT in tricuspid annular plane systolic excursion (TAPSE). TAPSE decreased by 3.0 mm [95% confidence interval (CI)=1.9-4.1 mm] in the AI group and 1.4 mm (95% CI=0.3-2.4 mm) in the non-AI group. In addition, left ventricular diastolic function decreased among patients using AI, as the mitral inflow E-wave decreased 5.8 cm/s (95% CI=1.8-9.7 ends) (p=0.006). Conclusion: The concurrent use of AI during RT for left-sided breast cancer led to a more pronounced change on right ventricular systolic function and left ventricular diastolic functions compared to RT alone.
机译：目的：左侧乳腺癌的辅助放疗对心脏健康有负面影响。发现在RT期间同时使用芳香酶抑制剂（AIs）可提高临床前模型中放射线的抗癌功效。我们评估了同时使用AI能否增强RT对心脏功能的急性影响。患者和方法：60例早期左侧乳腺癌的患者在辅助乳腺癌放疗前后均进行了二维超声心动图，心电图和心脏生物标志物测量。根据AI的使用情况，将数据分为两组。结果：我们观察到三尖瓣环平面收缩期偏移（TAPSE）期间，RT期间右心室收缩功能显着降低（p <0.05）。 AI组的TAPSE降低了3.0 mm [95％置信区间（CI）= 1.9-4.1 mm]，非AI组的TAPSE降低了1.4 mm（95％CI = 0.3-2.4 mm）。此外，使用AI的患者中左心室舒张功能下降，因为二尖瓣流入E波下降5.8 cm / s（95％CI = 1.8-9.7终点）（p = 0.006）。结论：与单独使用RT相比，在RT期间同时使用AI治疗左侧乳腺癌会导致右心室收缩功能和左心室舒张功能的变化更为明显。

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