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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines
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Antiproliferative Activities of Fagara xanthoxyloides and Pseudocedrela kotschyi Against Prostate Cancer Cell Lines

机译：Fagara xanthoxyloides和Pseudocedrela kotschyi对前列腺癌细胞系的抗增殖活性。

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Background/Aim: Roots of Fagara zanthoxyloides and Pseudocedrela kotchyii are used as chewing sticks and as medicinal remedies for diarrhea, cough and fever in West Africa. Extracts of the two plants also possess anti-bacterial, anti:fungal and anti-malarial activities. The aim of the present study was to determine the effects of such extracts on the growth, proliferation and induction of apoptosis in four prostate cancer cell lines. Materials and Methods. Androgen-independent PC3 and DU-145 and androgen-dependent LNCaP and CWR-22 prostate cancer cell lines were cultured for jive days with different concentrations of the extracts and examined for growth inhibition and evidence of apoptosis. Results: Irrespective of their androgen dependence, all four cancer cell lines exhibited a dose-dependent decrease in cell proliferation and viability by the 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT) assay and in induction of apoptosis. The results also show that LNCap cells were the most sensitive to the two extracts, with highest inhibition at day 3 and exhibiting the highest rate of apoptosis. Conclusion. These observations suggest that F. zanthoxyloides and P. kotchyii could serve as potential chemopreventive agents in the treatment of prostate cancer.
机译：背景/目的：根系Fagara zanthoxyloides和Pseudocedrela kotchyii用作咀嚼棒，并用作西非腹泻，咳嗽和发烧的药物。两种植物的提取物还具有抗菌，抗真菌和抗疟疾的活性。本研究的目的是确定这些提取物对四种前列腺癌细胞系的生长，增殖和凋亡诱导的影响。材料和方法。将雄激素非依赖性PC3和DU-145以及雄激素非依赖性LNCaP和CWR-22前列腺癌细胞系与不同浓度的提取物培养一整天，并检查其生长抑制和凋亡迹象。结果：不管它们对雄激素的依赖性如何，所有四种癌细胞系均通过3- [4,5-二甲基噻唑-2yl] -2,5-二苯基四氮唑溴化物（MTT）测定并在细胞中显示出剂量依赖性的细胞增殖和活力降低。诱导细胞凋亡。结果还表明，LNCap细胞对这两种提取物最敏感，在第3天抑制作用最高，并且凋亡率最高。结论。这些观察结果表明，花椒F. zanthoxyloides和P. kotchyii可以作为潜在的化学预防剂治疗前列腺癌。

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