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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia
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Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia

机译：PER3表达的上调与急性白血病更好的临床结果相关

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摘要

Background: Altered expression of circadian clock genes has been linked to various types of cancer. This study aimed to investigate whether these genes are also altered in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Materials and Methods: The expression profiles of nine circadian clock genes of peripheral blood (PB) leukocytes from patients with newly-diagnosed AML (n=41), ALL (n=23) and healthy individuals (n=51) were investigated. Results: In AML, the expression of period 1 (PER1), period 2 (PER2), period 3 (PER3), cryptochrome 1 (CRY1), cryptochrome 2 (CRY2), brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like 1 (BMAL1), and timeless (TIM) was significantly down-regulated, while that of CK1 epsilon was significantly up-regulated. In ALL, the expression of PER3 and CRY1 was significantly down-regulated, whereas those of CK1 epsilon and TIM were significantly up-regulated. Recovery of PER3 expression was observed in both patients with AML and those with ALL who achieved remission but not in patients who relapsed after treatment. Conclusion: Circadian clock genes are altered in patients with acute leukemia and up-regulation of PER3 is correlated with a better clinical outcome.
机译：背景：昼夜节律时钟基因表达的改变与各种类型的癌症有关。这项研究旨在调查这些基因在急性髓细胞性白血病（AML）和急性淋巴性白血病（ALL）中是否也发生了改变。材料与方法：研究了新诊断为AML（n = 41），ALL（n = 23）和健康个体（n = 51）患者外周血（PB）白细胞的9个昼夜节律基因的表达谱。结果：在AML中，周期1（PER1），周期2（PER2），周期3（PER3），隐色1（CRY1），隐色2（CRY2），脑和肌肉芳烃受体核转运子（ARNT）的表达-像1（BMAL1）和timeless（TIM）显着下调，而CK1 epsilon的显着上调。在ALL中，PER3和CRY1的表达显着下调，而CK1ε和TIM的表达显着上调。在AML患者和ALL缓解患者中均观察到PER3表达的恢复，但在治疗后复发的患者中未观察到。结论：急性白血病患者的昼夜节律基因发生改变，PER3的上调与更好的临床预后相关。

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