...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia
【24h】

Up-regulation of PER3 Expression Is Correlated with Better Clinical Outcome in Acute Leukemia

机译：均表达的上调与急性白血病更好的临床结果相关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Altered expression of circadian clock genes has been linked to various types of cancer. This study aimed to investigate whether these genes are also altered in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Materials and Methods: The expression profiles of nine circadian clock genes of peripheral blood (PB) leukocytes from patients with newly-diagnosed AML (n=41), ALL (n=23) and healthy individuals (n=51) were investigated. Results: In AML, the expression of period 1 (PER1), period 2 (PER2), period 3 (PER3), cryptochrome 1 (CRY1), cryptochrome 2 (CRY2), brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like 1 (BMAL1), and timeless (TIM) was significantly down-regulated, while that of CK1 epsilon was significantly up-regulated. In ALL, the expression of PER3 and CRY1 was significantly down-regulated, whereas those of CK1 epsilon and TIM were significantly up-regulated. Recovery of PER3 expression was observed in both patients with AML and those with ALL who achieved remission but not in patients who relapsed after treatment. Conclusion: Circadian clock genes are altered in patients with acute leukemia and up-regulation of PER3 is correlated with a better clinical outcome.
机译：背景：昼夜钟表基因的改变表达已与各种类型的癌症相关联。本研究旨在调查这些基因是否也在急性髓性白血病（AML）和急性淋巴白血病（全部）中改变。材料和方法：研究了新诊断的AML（n = 41）患者的外周血（Pb）白细胞的九昼夜血液（Pb）白细胞表达谱，所有（n = 23）和健康个体（n = 51）。结果：在AML，期间1（PER1），期间2（PER2），3（PER3），加密色谱1（CRY3），脑袋和肌肉芳基烃受体核转移率（ARNT）的表达与1（BMA1）相似，无论如何，TIMENTE（TIM）显着下调，而CK1 epsilon的显着上调。总而言之，PER3和CRY1的表达显着下调，而CK1ε和TIM的表达明显上调。在患有AML的患者中观察到均表达的恢复，并在治疗后重复的患者中取得缓解的患者。结论：昼夜节律钟表基因被急性白血病患者改变，占PER3的上调与更好的临床结果相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号