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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Systemic Treatment Options for Epithelioid Haemangioendothelioma: The Royal Marsden Hospital Experience
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Systemic Treatment Options for Epithelioid Haemangioendothelioma: The Royal Marsden Hospital Experience

机译：上皮样血管内皮瘤的全身治疗选择：皇家马斯登医院的经验

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Background: Epithelioid haemangioendothelioma (EHE) is a rare vascular tumour, which can arise at any site. There is little published data about the management of these tumours. Patients and Methods: A retrospective review of patients with histologically-proven EHE presenting to the Royal Marsden Hospital from January 1999 to January 2012. Results: Thirty-two patients (23 females) were identified with a median age of 44 (range=17-78). Twenty patients presented with diffuse disease. Median overall survival (OS) was 9.8 years in 10 patients with operable disease. Amongst those with inoperable disease (n=22), patients with liver disease had the longest median OS (9.8 years), while those with lung and mediastinal disease had the shortest OS (3.6 years). A variety of treatments were used for inoperable disease with infrequent radiological responses. Conclusion: The clinical behaviour can vary depending on the site of disease. Surgery, if feasible, has the best outcome. In those with inoperable disease, a period of observation to assess the tumour behaviour is recommended. The role of medical therapy remains unclear.
机译：背景：上皮类血管内皮瘤（EHE）是一种罕见的血管肿瘤，可发生在任何部位。关于这些肿瘤的治疗的公开数据很少。患者与方法：回顾性回顾了1999年1月至2012年1月在皇家马斯登医院就诊的经组织学证实的EHE的患者。结果：确定了32例患者（23名女性），中位年龄为44岁（范围= 17- 78）。 20名患者出现弥漫性疾病。 10名可手术疾病患者的中位总生存期（OS）为9.8年。在那些无法手术的患者中（n = 22），肝病患者的中位OS最长（9.8年），而患有肺和纵隔疾病的患者的OS最短（3.6年）。对于不能手术且放射反应不频繁的疾病，采用了多种治疗方法。结论：临床行为因疾病部位而异。如果可行，手术效果最好。对于那些无法手术的患者，建议进行观察以评估肿瘤的行为。药物治疗的作用尚不清楚。

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