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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Cancer Stem Cell Marker in Circulating Tumor Cells: Expression of CD44 Variant Exon 9 Is Strongly Correlated to Treatment Refractoriness, Recurrence and Prognosis of Human Colorectal Cancer
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Cancer Stem Cell Marker in Circulating Tumor Cells: Expression of CD44 Variant Exon 9 Is Strongly Correlated to Treatment Refractoriness, Recurrence and Prognosis of Human Colorectal Cancer

机译：循环肿瘤细胞中的癌症干细胞标记：CD44变异外显子9的表达与人类结直肠癌的治疗难治性，复发和预后密切相关

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Background/Aim: The expression of the CD44 variant exon 9 (CD44v9) was investigated in order to elucidate its significance for cancer stem cells in circulating human colorectal cancer cells (CTCs). Materials and Methods: After peripheral blood was drawn from patients with colorectal cancer, CTCs were collected. Using the reverse transcription-polymerase chain reaction method, we examined the relationship between expression of CD44v9 mRNA and prognosis. Results: In 60 out of 150 patients with colorectal cancer, expression of CD44v9 mRNA was positive in CTCs. In patients with stage III disease, the 5-year survival rate was 89% for patients with negative CD44v9 expression, whereas it was 52.4% in patients with positive expression (p<0.05). In patients with stage IV unresectable cancer, the 2-year survival rate was 70.1% in cases with CD44v9-negative expression and 33.3% in cases of positive expression (p<0.05). Conclusion: CD44v9 mRNA in the CTCs of colorectal cancer is useful as a factor predicting recurrence, prognosis, and treatment efficacy.
机译：背景/目的：研究了CD44变异外显子9（CD44v9）的表达，以阐明其在循环人结肠直肠癌细胞（CTC）中对癌干细胞的重要性。材料与方法：从结直肠癌患者中抽取外周血后，收集四氯化碳。使用逆转录-聚合酶链反应方法，我们检查了CD44v9 mRNA的表达与预后之间的关系。结果：在150例大肠癌患者中，有60例CTC中CD44v9 mRNA的表达为阳性。在III期疾病患者中，CD44v9表达阴性的患者的5年生存率是89％，而表达阳性的患者的5年生存率是52.4％（p <0.05）。在IV期不可切除的癌症患者中，CD44v9阴性表达的患者的2年生存率为70.1％，阳性表达的患者的2年生存率为33.3％（p <0.05）。结论：大肠癌CTCs中的CD44v9 mRNA可作为预测复发，预后和治疗效果的因素。

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