...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >PCK3145 Inhibits Proliferation and Induces Apoptosis in Breast and Colon Cancer Cells
【24h】

PCK3145 Inhibits Proliferation and Induces Apoptosis in Breast and Colon Cancer Cells

机译：PCK3145抑制乳腺癌和结肠癌细胞的增殖并诱导其凋亡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim: To explore the effects of PCK3145 beyond prostate cancer. Materials and Methods: Using Trypan blue, MTT proliferation assays, cell cycle and apoptosis analysis, we assessed the effects of PCK3145 on prostate (PC-3). breast (MCF-7) and colon (HT-29) human cancer cell lines and in osteosarcoma (MG-63) cells; any synergistic effects with docetaxel and oxaliplatin were also explored. Results: PCK3145 inhibited proliferation and induced apoptosis of PC-3, MCF-7 and HT-29 cells in a dose- and time-dependent manner but not in the MG-63 cell line, consistent with the low expression of the laminin receptor (LR) in the latter cell line. PCK3145 produced rapid (within 5min) and transient (up to 60 min) activation of MEK and ERK1/2. Synergistic effects were observed with docetaxel and oxaliplatin. Conclusion: PCK3145 can exert anticancer activity not only on prostate but also on breast and colon cancer cells, possibly through LR-mediated activation of MEK and ERK1/2 phosphorylation.
机译：目的：探讨PCK3145在前列腺癌之外的作用。材料和方法：使用锥虫蓝，MTT增殖测定，细胞周期和凋亡分析，我们评估了PCK3145对前列腺（PC-3）的作用。乳腺癌（MCF-7）和结肠（HT-29）人类癌细胞系以及骨肉瘤（MG-63）细胞;还探讨了与多西他赛和奥沙利铂的任何协同作用。结果：PCK3145以剂量和时间依赖性方式抑制PC-3，MCF-7和HT-29细胞的增殖并诱导其凋亡，但在MG-63细胞系中却没有，这与层粘连蛋白受体的低表达相一致（ LR）。 PCK3145产生了MEK和ERK1 / 2的快速激活（5分钟内）和短暂激活（最多60分钟）。观察到多西他赛和奥沙利铂具有协同作用。结论：PCK3145不仅可能对前列腺，而且对乳腺癌和结肠癌细胞具有抗癌活性，可能是通过LR介导的MEK激活和ERK1 / 2磷酸化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号