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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Paucity of Tumor-infiltrating Lymphocytes Is an Unfavorable Prognosticator and Predicts Lymph Node Metastases in Cutaneous Melanoma Patients
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Paucity of Tumor-infiltrating Lymphocytes Is an Unfavorable Prognosticator and Predicts Lymph Node Metastases in Cutaneous Melanoma Patients

机译：肿瘤浸润淋巴细胞少是不良的预后，并预测皮肤黑色素瘤患者的淋巴结转移。

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Background/Aim: Tumor infiltrating lymphocytes (TILs) have been a subject of growing scientific interest; however, a full picture of their role in cancer pathogenesis is still unclear. The present study aimed to reveal correlations between TIL grade and clinicopathological features, especially 5-year survival parameters in cutaneous malignant melanoma (CMM) patients. Materials and Methods: Presence of TILs was assessed by hematoxylin and eosin staining in routine diagnostic histopathological specimens from 104 patients with cutaneous melanoma. Results: In the entire group of 104 patients, decreasing TIL intensity was a highly negative prognostic factor and indicated considerably shorter overall survival (OS), cancer-specific overall survival (CSOS) and disease-free survival (DFS). We also report on a significant association between decreased TIL intensity and worse prognosis in lymph node-negative patients. Shorter survival (p=0.002 for OS, p=0.038 for CSOS and p=0.011 for DFS) was observed in patients with negative sentinel lymph node biopsies (SLNB), as well as in patients with lack of metastases in regional lymph nodes (p=0.034 for OS, p<0.001 for CSOS and DFS). Conclusion: Our results indicate that TIL grade is a valuable diagnostic parameter that may be helpful in risk stratification in CMM.
机译：背景/目的：肿瘤浸润淋巴细胞（TILs）已经成为越来越重要的科学兴趣。然而，尚不清楚它们在癌症发病机理中的作用的全貌。本研究旨在揭示皮肤恶性黑色素瘤（CMM）患者的TIL等级与临床病理特征，尤其是5年生存参数之间的相关性。材料和方法：在104例皮肤黑色素瘤患者的常规诊断性组织病理学标本中，通过苏木精和曙红染色评估了TIL的存在。结果：在整个104例患者中，降低的TIL强度是高度阴性的预后因素，表明总体生存期（OS），癌症特异性总体生存期（CSOS）和无病生存期（DFS）明显缩短。我们还报告了淋巴结阴性患者的TIL强度降低与预后较差之间的显着相关性。前哨淋巴结活检阴性（SLNB）以及区域淋巴结无转移的患者的生存期较短（OS的p = 0.002，CSOS的p = 0.038，DFS的p = 0.011）对于OS = 0.034，对于CSOS和DFS，p <0.001）。结论：我们的结果表明，TIL等级是有价值的诊断参数，可能有助于CMM的风险分层。

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