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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Impact of Adjuvant Pelvic Radiotherapy in Stage I Uterine Sarcoma
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Impact of Adjuvant Pelvic Radiotherapy in Stage I Uterine Sarcoma

机译:辅助盆腔放疗对Ⅰ期子宫肉瘤的影响

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Background/Aim: The optimal adjuvant therapy for stage I uterine sarcoma remains unresolved and may consist of radiotherapy (RT), chemotherapy, hormonal therapy or observation. We analyzed the impact of adjuvant pelvic RT on overall survival (OS), cause-specific survival (CSS), disease-free survival (DFS), pelvic control (PC) and patterns of failure. Patients and Methods: A retrospective analysis of 157 patients with International Federation of Gynecology and Obstetrics FIGO stage I uterine sarcoma was performed. RT was given postoperatively to a dose of 4551 Gy in 28-30 fractions. Results: The 5-year OS, CSS, DFS and PC was 58%, 62%, 47% and 72%, respectively. Adjuvant RT significantly improved PC (85% for RT group vs. 64% for non-RT group; p=0.02) but did not impact OS, CSS or DFS. Conclusion: The addition of adjuvant pelvic RT significantly improved PC for patients with stage 1 uterine sarcoma. As systemic therapies continue to improve, optimal locoregional control may result in improved patient outcomes.
机译:背景/目的:I期子宫肉瘤的最佳辅助治疗仍未解决,可能包括放疗(RT),化学疗法,激素治疗或观察。我们分析了辅助性盆腔RT对总生存期(OS),特定原因生存期(CSS),无病生存期(DFS),盆腔控制(PC)和失败模式的影响。患者与方法:对157例国际妇产科联合会FIGO I期子宫肉瘤患者进行回顾性分析。术后给予RT剂量28-30份的4551 Gy。结果:5年OS,CSS,DFS和PC分别为58%,62%,47%和72%。辅助放疗显着改善了PC(RT组为85%,非RT组为64%; p = 0.02),但不影响OS,CSS或DFS。结论:骨盆RT辅助治疗可显着改善1期子宫肉瘤患者的PC。随着全身疗法的不断改善,局部区域的最佳控制可能会改善患者的预后。

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