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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Presence of CD3-Positive T-Cells in Oral Premalignant Leukoplakia Indicates Prevention of Cancer Transformation
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Presence of CD3-Positive T-Cells in Oral Premalignant Leukoplakia Indicates Prevention of Cancer Transformation

机译：口腔癌变前白斑中CD3阳性T细胞的存在表明预防癌症转化

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摘要

Aim: Leukoplakias (LPLs) are lesions in the oral mucosa that have a potential to transform into oral squamous cell carcinoma (OSCC). As the degree of immunosurveillance may be important for this transformation to occur, the aim of this study was to determine the presence of immune cells in LPLs with dysplasia in relation to later development of OSCC. Materials and Methods: Biopsies from 16 patients with clinical diagnosis of LPL and histopathological diagnosis of hyperkeratosis with dysplasia were immunostained with antibodies to detect CD3(+) T cells, CD1a(+) LCs, Ki-67(+) and p53-expressing cells. Patients were divided into two groups: LPL with dysplasia that transformed into OSCC (LPL-dys) and that which did not (LPL-ca). Results: Quantitative analyses showed significantly lower numbers of CD3+ T-cells in LPL-ca than in LPL-dys. No significant differences were detected when comparing LPL-dys and LPL-ca regarding CD1a(+), p53(+) and Ki-67(+) cells. Conclusion: The number of CD3-expressing T-cells may be important for preventing malignant transformation of LPL.
机译：目的：白斑（LPL）是口腔粘膜中的病变，有可能转化为口腔鳞状细胞癌（OSCC）。由于免疫监视的程度可能对这种转化的发生很重要，因此本研究的目的是确定与发育异常的OSCC有关的具有发育异常的LPL中存在免疫细胞。材料和方法：对16例临床诊断为LPL且组织病理学确诊为增生不全的角化病的患者进行活检，并用抗体免疫染色，以检测CD3（+）T细胞，CD1a（+）LC，Ki-67（+）和p53表达细胞。将患者分为两组：非典型增生的LPL转化为OSCC（LPL-dys），非典型增生的LPL（LPL-ca）。结果：定量分析显示，LPL-ca中的CD3 + T细胞数量明显少于LPL-dys。比较LPL-dys和LPL-ca关于CD1a（+），p53（+）和Ki-67（+）细胞时，未检测到显着差异。结论：表达CD3的T细胞数目可能对预防LPL的恶性转化很重要。

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