Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine

ZvadaS.P.; DentiP.; GeldenhuysH.; MeredithS.; VanAsD.; HatherillM.; HanekomW.; WiesnerL.; SimonssonU.S.H.; JindaniA.; HarrisonT.; McIlleronH.M.

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Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine

机译：莫西沙星在肺结核患者中的药代动力学及间歇性大剂量利福喷汀的作用

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We described the population pharmacokinetics of moxifloxacin and the effect of high-dose intermittent rifapentine in patients with pulmonary tuberculosis who were randomized to a continuation-phase regimen of 400 mg moxifloxacin and 900 mg rifapentine twice weekly or 400 mg moxifloxacin and 1,200 mg rifapentine once weekly. A two-compartment model with transit absorption best described moxifloxacin pharmacokinetics. Although rifapentine increased the clearance of moxifloxacin by 8% during antituberculosis treatment compared to that after treatment completion without rifapentine, it did not result in a clinically significant change in moxifloxacin exposure.

机译：我们描述了莫西沙星的群体药代动力学和大剂量间歇性利福喷汀在肺结核患者中的作用，这些患者随机分为连续期方案，每周两次400 mg莫西沙星和900 mg利福喷汀，每周一次400 mg莫西沙星和1200 mg利福喷汀。具有转运吸收的两室模型最能说明莫西沙星的药代动力学。尽管与未使用利福喷汀的治疗完成后相比，利福喷汀在抗结核治疗期间将莫西沙星的清除率提高了8％，但并未导致莫西沙星暴露量的临床显着变化。

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《Antimicrobial agents and chemotherapy.》 |2012年第8期|共3页
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ZvadaS.P.; DentiP.; GeldenhuysH.; MeredithS.; VanAsD.; HatherillM.; HanekomW.; WiesnerL.; SimonssonU.S.H.; JindaniA.; HarrisonT.; McIlleronH.M.;
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1. Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine [J] . ZvadaS.P., DentiP., GeldenhuysH., Antimicrobial agents and chemotherapy. . 2012,第8期

机译：莫西沙星在肺结核患者中的药代动力学及间歇性大剂量利福喷汀的作用
2. Repeated administration of high-dose intermittent rifapentine reduces rifapentine and moxifloxacin plasma concentrations. [J] . Dooley K, Flexner C, Hackman J, Antimicrobial agents and chemotherapy. . 2008,第11期

机译：重复给予大剂量间歇性利福喷汀可降低利福喷汀和莫西沙星的血浆浓度。
3. Efficient intermittent rifapentine-moxifloxacin-containing short-course regimen for treatment of tuberculosis in mice. [J] . Veziris N, Lounis N, Chauffour A, Antimicrobial agents and chemotherapy. . 2005,第10期

机译：高效间歇性利福喷丁-莫西沙星短疗程治疗小鼠结核病。
4. Effects of Rifapentine and Rifampicin in Smear-positive Pulmonary Tuberculosis Patients and the Incidence Comparison of Complications [C] . Jianmei Ma, Hongyang Shi, Yan Zhang International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences . 2018

机译：利福平和利福平在涂型肺结核患者中的影响及并发症的发生率比较
5. Improving the treatment of experimental tuberculosis with combined rifapentine- and moxifloxacin-containing drug regimens. [D] . Rosenthal, Ian M. 2007

机译：联合利福喷汀和莫西沙星的药物治疗方案改善实验性结核的治疗。
6. Moxifloxacin Population Pharmacokinetics in Patients with Pulmonary Tuberculosis and the Effect of Intermittent High-Dose Rifapentine [O] . Simbarashe P. Zvada, Paolo Denti, Hennie Geldenhuys, 2012

机译：莫西沙星在肺结核患者中的药代动力学和间歇性大剂量利福喷汀的影响
7. Repeated Administration of High-Dose Intermittent Rifapentine Reduces Rifapentine and Moxifloxacin Plasma Concentrations▿ [O] . Dooley, Kelly, Flexner, Charles, Hackman, Judith, 2008

机译：重复服用大剂量间歇性利福喷汀可降低利福喷汀和莫西沙星血浆浓度▿

Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine

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