KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

BremmerD.N.; ClancyC.J.; PressE.G.; AlmaghrabiR.; ChenL.; DoiE.Y.; NguyenM.H.; ShieldsbR.K.

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KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

机译：带有KAC的带有AAC（6'）-的肺炎克雷伯菌菌株

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The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30% and 85% of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90% of the strains, indicating that the combination may overcome resistance.

机译：氨基糖苷修饰酶AAC（6'）-Ib在耐碳青霉烯类的肺炎克雷伯菌（CR-Kp）菌株中很常见。我们调查了对20个AAC（6'）-Ib产生CR-Kp菌株的丁胺卡那霉素（AMK）活性。 MIC聚集在16到32μg/ ml之间。通过时间杀灭研究，AMK（1倍和4倍MIC）分别针对30％和85％的菌株杀菌。然而，在可达到的人血清浓度下，大多数菌株显示出再生长，表明AAC（6'）-Ib赋予中等AMK抗性。 AMK和甲氧苄啶-磺胺甲基恶唑（TMP-SMX）对90％的菌株具有协同作用，表明该组合可克服耐药性。

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《Antimicrobial agents and chemotherapy.》 |2014年第12期|共4页
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BremmerD.N.; ClancyC.J.; PressE.G.; AlmaghrabiR.; ChenL.; DoiE.Y.; NguyenM.H.; ShieldsbR.K.;
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1. KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')- [J] . BremmerD.N., ClancyC.J., PressE.G., Antimicrobial agents and chemotherapy. . 2014,第12期

机译：带有KAC的带有AAC（6'）-的肺炎克雷伯菌菌株
2. Identification of strain harboring both aac(6')-Ib and aac(6')-Ib-cr variant simultaneously in Escherichia coli and Klebsiella pneumoniae [J] . Yun-Tae Kim, Ji-Hyun Jang, Hyun-Chul Kim, BMB Reports . 2011,第4期

机译：在大肠杆菌和Klebsiella肺炎中同时鉴定患AAC（6'） - IB和AAC（6'） - IB-CR变体的菌株
3. Predictive models for identification of hospitalized patients harboring KPC-producing klebsiella pneumoniae [J] . TumbarelloM., TrecarichiE.M., TumiettoF., Antimicrobial agents and chemotherapy. . 2014,第6期

机译：识别携带KPC产生的肺炎克雷伯菌的住院患者的预测模型
4. Development isolation and characterisation of a new non-virulent mimosine-degrading Klebsiella pneumoniae strain from the rumen liquor of German steers by using IBT-Goettinger bioreactor [C] . A. Aung, Uter Meulen, F. Gessler, International Grassland Congress . 2013

机译：使用IBT-Goettinger生物反应器，从德国操纵器瘤胃瘤芽的新型非毒力咪喹蛋白降解的Klebsiella肺炎肺炎的显影分离与表征
5. Antimicrobial treatment of experimental infection due to an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain [D] . Mathe, Andras 2007

机译：产生大范围β-内酰胺酶的肺炎克雷伯氏菌菌株对实验性感染的抗菌治疗
6. KPC-Producing Klebsiella pneumoniae Strains That Harbor AAC(6′)-Ib Exhibit Intermediate Resistance to Amikacin [O] . Derek N. Bremmer, Cornelius J. Clancy, Ellen G. Press, 2014

机译：带有AAC（6）-Ib的KPC生产肺炎克雷伯菌菌株对阿米卡星具有中等抗性
7. KPC-Producing Klebsiella pneumoniae Strains That Harbor AAC(6′)-Ib Exhibit Intermediate Resistance to Amikacin [O] . Derek N. Bremmer, Cornelius J. Clancy, Ellen G. Press, 2014

机译：奎宫生产的Klebsiella肺炎群菌株，港口AAC（6'） - IB表现出对Amikacin的中间抗性

KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

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