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Microsurface plasmon resonance biosensing based on gold-nanoparticle film

机译:基于金纳米粒子膜的微表面等离子体共振生物传感

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摘要

We use a gold-nanoparticle coated film to achieve highly spatially resolved biosensing that is based on localized surface-plasmon resonance. Unlike the planar gold film employed for conventional surface-plasmon resonance sensing, the gold-nanoparticle film relies exclusively on shifting of the peak extinction wavelength for detection of biointeraction and does not depend critically on the angle of incidence. These characteristics permit integration of surface-plasmon resonance with large-numerical-aperture optics to achieve biosensing with high sensitivity and spatial resolution as high as 25 μm.
机译:我们使用金纳米粒子涂层膜来实现基于局部表面等离子体共振的高度空间分辨的生物传感。与用于常规表面等离子体共振感应的平面金膜不同,金纳米粒子膜仅依赖于消光峰波长的移动来检测生物相互作用,而并不严格取决于入射角。这些特性允许将表面等离子体共振与大数值孔径光学器件集成在一起,从而以高灵敏度和高达25μm的空间分辨率实现生物传感。

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