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Polarization-sensitive optical coherence tomography for imaging human atherosclerosis

机译:偏振敏感光学相干断层扫描成像人的动脉粥样硬化

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Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with image contrast enhancement, which is based on its ability to detect phase retardation and the fast-axis angle. Both PS-OCT images and histopathology have demonstrated similar features that allowed differentiation of atherosclerotic structures (i.e., plaques) from normal tissue. Moreover, the picrosirius polarization method was used to confirm PS-OCT assessment of collagen in the fibrous cap of atherosclerotic plaques, and high-frequency (40 MHz) ultrasound images were used to identify calcium in the vessel wall. Our preliminary ex vivo investigation of human aortic specimens indicated that PS-OCT might help to identify atherosclerotic lesions.
机译:偏振敏感光学相干断层扫描(PS-OCT)将OCT的优势与图像对比度增强相结合,这是基于其检测相位延迟和快轴角度的能力。 PS-OCT图像和组织病理学均显示出相似的特征,可将动脉粥样硬化结构(即斑块)与正常组织区分开。此外,picrosirius极化方法用于确认PS-OCT评估动脉粥样硬化斑块纤维帽中胶原的含量,并使用高频(40 MHz)超声图像识别血管壁中的钙。我们对人体主动脉标本的初步离体调查表明,PS-OCT可能有助于识别动脉粥样硬化病变。

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