• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied optics >Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom
【24h】

Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom

机译：从测量的模拟乳房的幻像的漫透射率和反射率非线性重建吸收和荧光对比度

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We report on the nonlinear reconstruction of local absorption and fluorescence contrast in tissuelike scattering media from measured time-domain diffuse reflectance and transmittance of laser as well as laser-excited fluorescence radiation. Measurements were taken at selected source-detector offsets using slablike diffusely scattering and fluorescent phantoms containing fluorescent heterogeneities. Such measurements simulate in vivo data that would be obtained employing a scanning, time-domain fluorescence mammograph, where the breast is gently compressed between two parallel glass plates, and source and detector optical fibers scan synchronously at various source-detector offsets, allowing the recording of laser and fluorescence mammograms. The diffusion equations modeling the propagation of the laser and fluorescence radiation were solved in frequency domain by the finite element method simultaneously for several modulation frequencies using Fourier transformation and preprocessed experimental data. To reconstruct the concentration of the fluorescent contrast agent, the Born approximation including higher-order reconstructed photon densities at the excitation wavelength was used. Axial resolution was determined that can be achieved by various detection schemes. We show that remission measurements increase the depth resolution significantly.
机译：我们从测量的时域漫反射和激光以及激光激发的荧光辐射的透射率报告了组织状散射介质中局部吸收和荧光对比度的非线性重建。使用平板状的漫散射和包含荧光异质性的荧光体模，在选定的源探测器偏移处进行测量。这样的测量模拟了体内数据，这些数据将通过使用扫描时域荧光乳腺X线摄影机获得，在该数据中，乳房在两个平行玻璃板之间被轻轻挤压，并且源和检测器光纤以各种源-检测器偏移量进行同步扫描，从而可以进行记录激光和荧光乳腺X线照片。利用傅里叶变换和预处理的实验数据，同时针对多个调制频率，通过有限元方法同时在频域中求解了模拟激光和荧光辐射传播的扩散方程。为了重建荧光造影剂的浓度，使用了包括在激发波长处的高阶重建光子密度的Born近似。确定了可以通过各种检测方案实现的轴向分辨率。我们表明，缓解测量可以显着提高深度分辨率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号