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Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis

机译：脑海马的拉曼信号可能有助于阿尔茨海默氏病的诊断

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Micro-Raman spectroscopy (MRS) is used for the first time to our knowledge to investigate brain hippocampus tissue from Alzheimer's disease (AD) infected rats. In situ Raman analysis of tissue sections provides distinct spectra useful for distinguishing AD from normal state. The biochemical changes of brain hippocampus tissue including the deposit of beta-amyloid (A(beta)) protein, the increase of cholesterol, and hyperphosphorylated tau are observed through MRS when AD occurs. A more convincing multi-Raman criterion based on single Raman peaks, and further in combination with statistical analysis of the entire Raman spectrum, is found capable of classifying brain hippocampus tissues with different pathological features. This study demonstrates the brain hippocampus is an important candidate for considering the early pathological state of AD, and Raman signatures from the brain hippocampus could aid AD diagnosis. In addition, Raman results undoubtedly confirm simultaneous changes of cholesterol and A(beta) in the progression of AD.
机译：据我们所知，显微拉曼光谱法（MRS）首次用于研究阿尔茨海默氏病（AD）感染大鼠的脑海马组织。组织切片的原位拉曼分析提供了可用于区分AD与正常状态的独特光谱。当发生AD时，通过MRS观察到脑海马组织的生化变化，包括β-淀粉样蛋白（Aβ）的沉积，胆固醇的增加和tau蛋白的过度磷酸化。发现了基于单拉曼峰的更有说服力的多拉曼标准，并进一步与整个拉曼光谱的统计分析相结合，能够对具有不同病理特征的脑海马组织进行分类。这项研究表明，脑海马是考虑AD早期病理状态的重要候选人，而脑海马的拉曼信号可以帮助AD诊断。另外，拉曼结果无疑证实了AD进展中胆固醇和Aβ的同时变化。

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