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Design study of nanograting-based surface plasmon resonance biosensor in the near-infrared wavelength

机译:基于纳米光栅的近红外表面等离子体共振生物传感器的设计研究

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摘要

A key issue with surface plasmon resonance (SPR) biosensors, which are the focus of many researchers, is improving their sensitivity to detect lower amounts of analyte in a solution. Most SPR developments have focused on the grating-based sensitivity-enhancement approach. In addition to sensitivity, a substantial enhancement of other sensor characteristics such as resolution and signal-to-noise ratio (SNR) is desired for designing a practical sensor. So, in this paper, the characteristics of surface plasmon polaritons sustained by 1D subwavelength metallic gratings on a thin metal slab (under the Krestchmann configuration) have been investigated numerically for the analyte-ligand interactions detection. Effects of different structural parameters, such as grating period, grating depth, metal film thickness, and fill factor have been evaluated on the sensor sensitivity as well as resolution and SNR. Numerical results indicate that the sensor working in the near-infrared wavelength has a better performance than that in the visible one. The result of numerical investigation has been used to design an optimized sensor with the best figure of merit.
机译:表面等离子体激元共振(SPR)生物传感器的一个关键问题,是许多研究人员关注的焦点,是提高其检测溶液中少量分析物的灵敏度。大多数SPR开发都集中在基于光栅的灵敏度增强方法上。除了灵敏度之外,还需要大幅提高其他传感器特性,例如分辨率和信噪比(SNR),以设计实用的传感器。因此,在本文中,已经对由薄金属板上(在Krestchmann配置下)的一维亚波长金属光栅维持的表面等离激元极化子的特性进行了数值研究,以检测分析物与配体之间的相互作用。已经评估了不同结构参数(例如光栅周期,光栅深度,金属膜厚度和填充因子)对传感器灵敏度以及分辨率和SNR的影响。数值结果表明,在近红外波长下工作的传感器具有比可见光传感器更好的性能。数值研究的结果已被用于设计具有最佳品质因数的优化传感器。

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