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首页> 外文期刊>Inorganica Chimica Acta >Synthesis, structures and the biological activity study on the metal complexes of 2-(4-aminophenyl)benzothiazole derivative
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Synthesis, structures and the biological activity study on the metal complexes of 2-(4-aminophenyl)benzothiazole derivative

机译：2-（4-氨基苯基）苯并噻唑衍生物的金属配合物的合成，结构及生物活性研究

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(2-(4-(Benzothiazole)phenyl)carbamoylmethyl)iminodiacetic acid (ZL-5) was synthesized and then its three metal complexes were prepared with structures determined by ~1H NMR or X-ray. In all complexes, ZL-5 is deprotonated to generate the neutral complex unit and acts as a tetradentate ligand, providing iminodiacetic N atom and three O atoms to bond with metal ions. Meantime we studied on the interaction of complexes with DNA by ultraviolet spectrum and fluorescent spectrum. Also the cleavage abilities of the complexes on plasmid pBR 322 DNA were studied by gel electrophoresis. We deduce the Co(II) complex 1 with the largest planar structure has the strongest DNA binding ability mainly by the intercalation mode, while the Cu(II) complex 2 with the coordinated water cut the DNA most effectively. And in the oxidative cleavage process of all complexes, the hydroxyl radical is produced which can be captured by DMSO.
机译：合成了（2-（4-（苯并噻唑）苯基）氨基甲酰基甲基）亚氨基二乙酸（ZL-5），然后用〜1H NMR或X射线测定了结构的三种金属配合物。在所有络合物中，ZL-5被去质子化以生成中性络合物单元，并充当四齿配体，提供亚氨基二乙酸N原子和三个O原子与金属离子键合。同时，我们通过紫外光谱和荧光光谱研究了配合物与DNA的相互作用。还通过凝胶电泳研究了复合物在质粒pBR 322 DNA上的切割能力。我们推论出最大平面结构的Co（II）配合物1具有最强的DNA结合能力，这主要是通过插层模式，而配合水的Cu（II）配合物2最有效地切割了DNA。在所有配合物的氧化裂解过程中，都会产生羟基自由基，可被DMSO捕获。

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