Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity

Tabassum Sartaj; Ahmad Musheer; Afzal Mohd; Zaki Mehvash; Faizi Md. Serajul Haque; Ali Akram

首页> 外文期刊>Inorganica Chimica Acta >Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity

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Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity

机译：含1,10-菲咯啉和5-（2-羧苄氧基）间苯二甲酸的钴（II）混合配体配合物的合成及晶体结构测定：其生物学评价。 DNA /蛋白质结合图谱，pBR322 DNA裂解活性

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New metal-based cancer chemotherapeutic agent Co(II) complex of the type{[Co(Me(2)Phen)(o-cbiaH) (H2O)2]center dot H2O} (1) was synthesized from ligand 5-(2-carboxybenzyloxy)isophthalic acid (o-cbiaH(3)) and thoroughly characterized by spectroscopic and single crystal X-ray diffraction method. Complex 1 crystallizes in a slightly distorted octahedral CoN2O4 coordination environment. In vitro DNA binding studies of ligand and complex 1 with CT DNA were carried out by using biophysical techniques viz electronic absorption and fluorescence spectral studies which indicated that 1 binds to DNA more avidly as compared to ligand via electrostatic binding mode. Complex 1 shows significant DNA photo cleavage activity through the formation of hydroxyl radicals via photo-redox pathway. The affinity of 1 towards HSA was also investigated by the fluorescence spectroscopic technique and 3D scan measurements revealing that 1 quench the fluorescence intensity of HSA more strongly than o-cbiaH(3). Furthermore, magnetic drug targeting shows the accumulation of complex 1 in the target site under the influence of an externally applied magnetic force. (C) 2016 Elsevier B.V. All rights reserved.

机译：由配体5-（2）合成{{Co（Me（2）Phen）（o-cbiaH）（H2O）2]中心点H2O}（1）类型的新型金属基癌症化疗剂Co（II）配合物-羧基苄氧基）间苯二甲酸（o-cbiaH（3）），并通过光谱和单晶X射线衍射方法进行了全面表征。配合物1在稍微扭曲的八面体CoN2O4配位环境中结晶。配体和配合物1与CT DNA的体外DNA结合研究是通过使用生物物理技术进行的，即电子吸收和荧光光谱研究表明，与1种配体相比，通过静电结合方式与配体的结合更为亲和。配合物1通过光-氧化还原途径通过形成羟基自由基而显示出显着的DNA光裂解活性。还通过荧光光谱技术和3D扫描测量研究了1对HSA的亲和力，揭示了1比o-cbiaH（3）更强地淬灭HSA的荧光强度。此外，磁性药物靶向显示了复合物1在外部施加的磁力的影响下在靶部位的积累。（C）2016 Elsevier B.V.保留所有权利。

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《Inorganica Chimica Acta》 |2016年第null期|共11页
作者
Tabassum Sartaj; Ahmad Musheer; Afzal Mohd; Zaki Mehvash; Faizi Md. Serajul Haque; Ali Akram;
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正文语种 eng
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In vitro DNA binding; HSA binding; pBR322 DNA cleavage; Magnetic drug targeting;

机译：体外DNA结合;HSA结合;pBR322 DNA裂解;磁性药物靶向;

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1. Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity [J] . Tabassum Sartaj, Ahmad Musheer, Afzal Mohd, Inorganica Chimica Acta . 2016,第Null期

机译：含1,10-菲咯啉和5-（2-羧苄氧基）间苯二甲酸的钴（II）混合配体配合物的合成及晶体结构测定：其生物学评价。 DNA /蛋白质结合图谱，pBR322 DNA裂解活性
2. Synthesis, structure, DNA binding, cleavage and biological activity of cobalt (III) complexes derived from triethylenetetramine and 1,10 phenanthroline ligands [J] . H. Gopinathan, N. Komathi, M.N. Arumugham Inorganica Chimica Acta . 2014,第Null期

机译：三亚乙基四胺和1,10菲咯啉配体衍生的钴（III）配合物的合成，结构，DNA结合，裂解和生物学活性
3. Synthesis, crystal structures, DNA-binding properties, cytotoxic and antioxidation activities of several new ternary copper(II) complexes of N,N '-(p-xylylene)di-alanine acid and 1,10-phenanthroline [J] . Jia L, Jiang P, Xu J, Inorganica Chimica Acta . 2010,第5期

机译：N，N'-（对亚二甲苯基）二丙氨酸和1,10-菲咯啉的几种新型三元铜（II）配合物的合成，晶体结构，DNA结合特性，细胞毒性和抗氧化活性
4. Synthesis and Crystal Structure of a Cadmium(II) Complex with 2-(4'-Chlorine-benzoyl)-benzoic Acid and 1,10-Phenanthroline [C] . Xiumei Li, Zhitao Wang, Qingwei Wang International Conference on Materials and Products Manufacturing Technology . 2011

机译：用2-（4'-氯苯甲酰基） - 苯甲酸和1,10菲咯啉的镉（II）络合物的合成和晶体结构
5. Computer modeling of protein tertiary structure and DNA binding energetics. I. Empirical free energy analysis of the engrailed Q50K variant-DNA complex and its mutants. II. The predicted structure of the adenovirus E4 orf6 protein by threading and comparative protein modeling. [D] . Brown, Lawrence Milton, III. 2001

机译：蛋白质三级结构和DNA结合能学的计算机建模。 I.陷入困境的Q50K变异体-DNA复合体及其突变体的经验自由能分析。二。通过穿线和比较蛋白建模预测腺病毒E4 orf6蛋白的结构。
6. Synthesis and Biological Activity of Manganese (II) Complexes of Phthalic and Isophthalic Acid: X-Ray Crystal Structures of Mn(ph)(Phen)2(H2O)· 4H2O Mn(Phen)2(H2O)22(Isoph)2(Phen)· 12H2O and {Mn(Isoph)(bipy)4· 2.75biby}n(phH2 = Phthalic Acid; isoph = Isophthalic Acid; phen = 110-Phenanthroline; bipy = 22-Bipyridine) [O] . Michael Devereux, Malachy McCann, Vanessa Leon, 2000

机译：邻苯二甲酸和间苯二甲酸锰（II）配合物的合成和生物活性：Mn（ph）（Phen）2（H2O）·4H2OMn（Phen）2（H2O）2 2的X射线晶体结构（Isoph）2（Phen）·12H2O和{Mn（Isoph）（bipy） 4·2.75biby} n（phH2 =邻苯二甲酸; isoph =间苯二甲酸; phen = 110-邻菲咯啉; bipy = 22 -联吡啶）
7. Synthesis and Biological Activity of Manganese (II) Complexes of Phthalic and Isophthalic Acid: X-Ray Crystal Structures of [Mn(ph)(Phen)2(H2O)]· 4H2O, [Mn(Phen)2(H2O)2]2(Isoph)2(Phen)· 12H2O and {[Mn(Isoph)(bipy)]4· 2.75biby}n(phH2 = Phthalic Acid; isoph = Isophthalic Acid; phen = 1,10-Phenanthroline; bipy = 2,2-Bipyridine) [O] . Devereux, Michael, McCann, Malachy, Leon, Vanessa, 2000

机译：邻苯二甲酸和间苯二甲酸锰（II）配合物的合成和生物活性：[Mn（ph）（Phen）2（H2O）]·4H2O，[Mn（Phen）2（H2O）2] 2的X射线晶体结构（Isoph）2（Phen）·12H2O和{[Mn（Isoph）（bipy）] 4·2.75biby} n（phH2 =邻苯二甲酸; isoph =间苯二甲酸; phen = 1,10-邻菲咯啉; bipy = 2,2 -联吡啶）

Synthesis and crystal structure determination of cobalt(II) mixed-ligand complex containing 1,10-phenanthroline and 5-(2-carboxybenzyloxy)isophthalic acid: Their biological evaluation viz. DNA/protein binding profile, pBR322 DNA cleavage activity

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