Nanoparticles rapidly assess specific IgE in plasma

Ashraf S.; Qadri S.; Al-Ramadi B.; Haik Y.

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Nanoparticles rapidly assess specific IgE in plasma

机译：纳米颗粒可快速评估血浆中的特异性IgE

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Allergy is the sixth leading cause of chronic disease in the world. This study demonstrates the feasibility of detecting allergy indicators in human plasma, noninvasively, at the point of care and with a comparable efficiency and reduced turnaround time compared with the gold standard. Peanut allergy was utilized as a model due to its widespread occurrence among the US population and fatality if not treated. The detection procedure utilized magnetic nanoparticles that were coated with an allergen layer (peanut protein extract). Peanut immunoglobulin E (IgE) was detected in concentrations close to the minimum detection range of CAP assay. The results were obtained in minutes compared with the CAP assay which requires more than 3h.

机译：过敏是世界上慢性病的第六大主要原因。这项研究证明了在护理点以无创方式检测人血浆中过敏指标的可行性，并且与金标准相比具有相当的效率和缩短了周转时间。由于花生过敏症在美国人群中普遍存在，并且如果不加以治疗可导致死亡，因此被用作模型。检测程序利用了涂有过敏原层（花生蛋白提取物）的磁性纳米颗粒。花生免疫球蛋白E（IgE）的浓度接近CAP分析的最小检测范围。与需要3小时以上的CAP分析相比，几分钟即可获得结果。

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《Nanotechnology》 |2012年第30期|共7页
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Ashraf S.; Qadri S.; Al-Ramadi B.; Haik Y.;
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1. Nanoparticles rapidly assess specific IgE in plasma [J] . Ashraf S., Qadri S., Al-Ramadi B., Nanotechnology . 2012,第30期

机译：纳米颗粒可快速评估血浆中的特异性IgE
2. Increased plasma reactive oxidant levels and their relationship to blood cells, total IgE, and allergen-specific IgE levels in asthmatic children. [J] . Heidenfelder B, Johnson M, Hudgens E, The journal of asthma . 2010,第1期

机译：哮喘儿童血浆反应性氧化剂水平升高及其与血细胞，总IgE和过敏原特异性IgE水平的关系。
3. Increased plasma reactive oxidant levels and their relationship to blood cells, total IgE, and allergen-specific IgE levels in asthmatic children. [J] . Heidenfelder B, Johnson M, Hudgens E The journal of asthma . 2009,第7期

机译：哮喘儿童血浆反应性氧化剂水平升高及其与血细胞，总IgE和过敏原特异性IgE水平的关系。
4. Multiplexed, rapid point of care platform to quantify allergen-specific IgE [C] . Monroe M. R., Reddington A. P., Cretich M., 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：多重，快速的即时护理平台可量化过敏原特异性IgE
5. Peanut Allergic Children Residing in Olmsted County, MN: An Examination of the Prevalence in 2007, Incidence Rates from 1999--2007 and Association between Peanut-Specific IgE Level, Tolerance and Reaction Severity. [D] . Rinaldi, Maria Carol. 2011

机译：居住在明尼苏达州奥尔姆斯特德县的花生过敏儿童：2007年患病率调查，1999--2007年的发病率以及花生特异性IgE水平，耐受性和反应严重性之间的关联。
6. The distribution of IgE plasma cells in lymphoid and non-lymphoid tissues of high-IgE responder rats: differential localization of antigen-specific and bystander components of the IgE response to inhaled antigen. [O] . C McMenamin, B Girn, P G Holt 1992

机译：高IgE反应性大鼠的淋巴和非淋巴组织中IgE浆细胞的分布：IgE对吸入抗原的抗原特异性和旁观者成分的差异性定位。
7. Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils. [O] . Shona Wilson, Frances M Jones, Hassan K M Fofana, 2013

机译：通过治疗人血吸虫病诱导的血浆IL-5的快速增强依赖于抗原剂量，IgE和嗜酸性粒细胞。
8. Risk-Informed Decision-Making for Potential Inhalation of Plutonium-239 and -238 Dioxide Nanoparticles: Use of Default Assumptions and Material-Specific Data for Assessing Dose. [R] . L. J. Cash 2014

机译：潜在吸入钚-239和-238二氧化硅纳米粒子的风险信息决策：使用默认假设和材料特定数据评估剂量。

Nanoparticles rapidly assess specific IgE in plasma

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