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首页> 外文期刊>Nanotechnology >Cytotoxicity and photocytotoxicity of structure-defined water-soluble C_(60)/micelle supramolecular nanoparticles
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Cytotoxicity and photocytotoxicity of structure-defined water-soluble C_(60)/micelle supramolecular nanoparticles

机译：结构确定的水溶性C_（60）/胶束超分子纳米颗粒的细胞毒性和光细胞毒性

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摘要

Well-defined, water-soluble C_(60)/micelle hierarchical colloids with varied amounts of C_(60) sitting on the surface of micellar cores were prepared via the self-assembly of PS-b-PDMA block copolymer micelles and C_(60). The composites can generate a significant amount of reactive oxygen upon irradiation with red light. Cell studies showed that the colloids were either strongly associated with, or internalized by, the cells after 2h incubation, but did not show obvious toxicity in the dark. In contrast, efficient cell killing was observed when the colloid-incubated cells were exposed to red light. This indicates that the supramolecular colloids are promising as photosensitizers for photodynamic cancer therapy.
机译：通过自组装PS-b-PDMA嵌段共聚物胶束和C_（60）制备定义明确的，水溶性C_（60）/胶束分层胶体，其中C_（60）含量不同）。在用红光照射时，该复合材料可以产生大量的活性氧。细胞研究表明，胶体在孵育2小时后与细胞紧密结合或被细胞内化，但在黑暗中未显示出明显的毒性。相反，当将胶体培养的细胞暴露于红光下时，观察到有效的细胞杀伤作用。这表明超分子胶体有望用作光动力癌症治疗的光敏剂。

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