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首页> 外文期刊>Nanotechnology >Polymer hydrogel functionalized with biodegradable nanoparticles as composite system for controlled drug delivery
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Polymer hydrogel functionalized with biodegradable nanoparticles as composite system for controlled drug delivery

机译：用可生物降解的纳米粒子功能化的聚合物水凝胶作为控制药物输送的复合系统

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The possibility to direct pharmacological treatments targeting specific cell lines using polymer nanoparticles is one of the main novelties and perspectives in nanomedicine. However, sometimes, the ability to maintain NPs localized at the site of the injection that work as a drug reservoir can represent a good and complementary option. In this direction we built a composite material made of polymeric hydrogel functionalized with polymer NPs. epsilon-caprolactone and polyethylene glycol have been copolymerized in a two-step synthesis of PEGylated NPs, while hydrogel was synthesized through polycondensation between NPs, agarose and branched polyacrylic acid. NP functionalization was verified with Fourier transform infrared spectroscopy (FTIR), high resolution magic angle spinning-nuclear magnetic resonance (HRMAS-NMR) spectroscopy and release kinetics from a hydrogel matrix and compared with NPs only physically entrapped into a hydrogel matrix. The characteristics of the resulting composite hydrogel-NPs system were studied both in terms of rheological properties and in its ability to sustain the release of To-Pro3, used as a drug mimetic compound to represent a promising drug delivery device.
机译：使用聚合物纳米颗粒直接针对特定细胞系进行药理治疗的可能性是纳米医学的主要新颖性和前景之一。但是，有时，保持NP定位在注射部位（作为药物储库）的能力可以代表一个很好的补充选择。在这个方向上，我们构建了一种由聚合物水凝胶制成的复合材料，该聚合物被聚合物NP官能化。 ε-己内酯和聚乙二醇已在PEG化NP的两步合成中进行了共聚，而水凝胶是通过NP，琼脂糖和支链聚丙烯酸之间的缩聚而合成的。 NP功能化已通过傅立叶变换红外光谱（FTIR），高分辨率魔角旋转核磁共振（HRMAS-NMR）光谱进行了验证，并从水凝胶基质中释放出动力学，并与仅以物理方式包裹在水凝胶基质中的NP进行了比较。研究了所得复合水凝胶-NPs系统的特性，包括流变学性质和维持To-Pro3释放的能力，To-Pro3用作模拟药物的化合物，代表着有前途的药物递送装置。

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