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Tunable graphene quantum point contact transistor for DNA detection and characterization

机译：可调谐石墨烯量子点接触晶体管，用于DNA检测和表征

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摘要

A graphene membrane conductor containing a nanopore in a quantum point contact geometry is a promising candidate to sense, and potentially sequence, DNA molecules translocating through the nanopore. Within this geometry, the shape, size, and position of the nanopore as well as the edge configuration influences the membrane conductance caused by the electrostatic interaction between the DNA nucleotides and the nanopore edge. It is shown that the graphene conductance variations resulting from DNA translocation can be enhanced by choosing a particular geometry as well as by modulating the graphene Fermi energy, which demonstrates the ability to detect conformational transformations of a double-stranded DNA, as well as the passage of individual base pairs of a single-stranded DNA molecule through the nanopore.
机译：在量子点接触几何形状中包含纳米孔的石墨烯膜导体是有希望的候选物，其可感测并潜在地测序穿过纳米孔的DNA分子。在这种几何形状内，纳米孔的形状，大小和位置以及边缘配置会影响由DNA核苷酸与纳米孔边缘之间的静电相互作用引起的膜电导。结果表明，通过选择特定的几何形状以及调节石墨烯费米能，可以增强由DNA易位引起的石墨烯电导率变化，这证明了检测双链DNA构象转化以及通过的能力。单链DNA分子的单个碱基对穿过纳米孔的过程。

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