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Serial weighting of micro-objects with resonant microchanneled cantilevers

机译：具有共振微通道悬臂的微对象的串行加权

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Atomic force microscopy (AFM) cantilevers have proven to be very effective mass sensors. The attachment of a small mass to a vibrating cantilever produces a resonance frequency shift that can be monitored, providing the ability to measure mass changes down to a few molecules resolution. Nevertheless, the lack of a practical method to handle the catch and release process required for dynamic weighting of microobjects strongly hindered the application of the technology beyond proof of concept measurements. Here, a method is proposed in which FluidFM hollow cantilevers are exploited to overcome the standard limitations of AFM-based mass sensors, providing high throughput single object weighting with picogram accuracy. The extension of the dynamic models of AFM cantilevers to hollow cantilevers was discussed and the effectiveness of mass weighting in air was validated on test samples.
机译：原子力显微镜（AFM）悬臂被证明是非常有效的质量传感器。将小质量的物质附着到振动的悬臂上会产生共振频率偏移，该频率可以被监测，从而能够测量质量变化直至几个分子的分辨率。然而，缺乏处理微物体动态加权所需的捕获和释放过程的实用方法，严重阻碍了该技术的应用，超出了概念验证的范围。在这里，提出了一种方法，其中利用FluidFM空心悬臂来克服基于AFM的质量传感器的标准局限性，从而提供具有皮克精度的高吞吐量单对象加权。讨论了将AFM悬臂动力学模型扩展到空心悬臂的问题，并在测试样品上验证了空气质量加权的有效性。

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