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首页> 外文期刊>Nanotechnology >Highly fluorescent resorcinarene cavitand nanocapsules with efficient renal clearance
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Highly fluorescent resorcinarene cavitand nanocapsules with efficient renal clearance

机译：具有高效肾脏清除功能的高荧光间苯二甲醚空洞纳米胶囊

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摘要

Nanomaterial based imaging approaches hold substantial promise in addressing current diagnostic and therapeutic challenges. One of the key requirements for the successful clinical translation of nanomaterials is their complete clearance from the body within a reasonable time period preferably via the renal filtration route. This article describes the synthesis of highly fluorescent, water soluble, resorcinarene cavitand nanocapsules and demonstrates their effective renal clearance in mice. The synthesis and functionalization of nanocapsules was accomplished in a one-pot operation via thiol-ene reactions without involving self-assembly, sacrificial templates or emulsions. Water soluble resorcinarene cavitand nanocapsules obtained by this approach were covalently functionalized with Alexa Fluor 750. Highly fluorescent nanocapsules with hydrodynamic diameters of 122 nm and 68 nm and extinction coefficients of 1.3 x 10(9)M(-1) cm(-1) and 1.5 x 10(8)M(-1) cm(-1) respectively were prepared by varying the reaction conditions. The in vivo biodistribution and clearance of these nanocapsules in mice followed by whole-body fluorescence imaging showed that they were both cleared renally within a few hours. Given the inherent encapsulation capabilities of nanocapsules, the renal clearance demonstrated in this work opens up new opportunities for their theranostic applications especially for targeting and treating the urinary tract.
机译：基于纳米材料的成像方法在解决当前的诊断和治疗挑战方面具有广阔的前景。纳米材料成功临床翻译的关键要求之一是在合理的时间内，最好是通过肾脏过滤途径，将它们从体内完全清除。本文介绍了高荧光，水溶性，间苯二甲烯腔和纳米囊的合成，并证明了它们在小鼠中的有效肾脏清除率。纳米胶囊的合成和功能化通过硫醇-烯反应在一锅操作中完成，而无需涉及自组装，牺牲模板或乳液。通过此方法获得的水溶性间苯二甲烯卡维酮纳米胶囊与Alexa Fluor 750共价官能化。高荧光纳米胶囊的流体力学直径为122 nm和68 nm，消光系数为1.3 x 10（9）M（-1）cm（-1）和通过改变反应条件分别制备1.5 x 10（8）M（-1）cm（-1）。这些纳米胶囊在小鼠中的体内生物分布和清除，然后进行全身荧光成像显示，它们均在数小时内被肾脏清除。鉴于纳米胶囊固有的包囊能力，这项工作中证明的肾脏清除能力为它们的血管扩张治疗应用打开了新的机遇，尤其是针对和治疗尿路。

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