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首页> 外文期刊>Nanotechnology >Nanomechanical probing of soft matter through hydrophobic AFM tips fabricated by two-photon polymerization
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Nanomechanical probing of soft matter through hydrophobic AFM tips fabricated by two-photon polymerization

机译：通过双光子聚合制备的疏水AFM尖端对软物质进行纳米力学探测

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摘要

Atomic force microscopy (AFM) nanoindentation of soft materials is a powerful tool for probing mechanical properties of biomaterials. Though many results have been reported in this field over the last decade, adhesion forces between the tip and the sample hinder the elastic modulus measurement when hydrophilic soft samples are investigated. Here, two-photon polymerization (2PP) technology was used to fabricate hydrophobic perfluoropolyether-based AFM tips. The hydrophobic 2PP tips allowed us to overcome the limitations of commercial and functionalized tips as well as to successfully measure the elastic modulus of medically relevant soft materials in air. Our results obtained in the characterization of poly(dimethyl siloxane) and polyethylene glycol hydrogels showed lower adhesion forces over a larger measurement range when compared to measurements performed with commercial tips. The elastic moduli measured by means of hydrophobic 2PP AFM tips were also found to be comparable to those obtained using conventional techniques for macroscopic samples. We successfully showed that the hydrophobic AFM tips developed by this highly versatile technology enable the study of mechanical properties of soft matter, benefiting from reduced sample-tip interactions, and a custom-made shape and dimension of the tips.
机译：软材料的原子力显微镜（AFM）纳米压痕是探测生物材料机械性能的强大工具。尽管在过去十年中已在该领域中报告了许多结果，但是当研究亲水性软样品时，针尖和样品之间的粘附力阻碍了弹性模量的测量。在此，使用了两光子聚合（2PP）技术来制造基于疏水性全氟聚醚的AFM针尖。疏水性2PP吸头使我们克服了商业化和功能化吸头的局限性，并成功地测量了医疗相关软材料在空气中的弹性模量。与使用商用吸头进行的测量相比，我们在聚二甲基硅氧烷和聚乙二醇水凝胶表征中获得的结果表明，在较大的测量范围内，其附着力较低。还发现借助疏水性2PP AFM尖端测量的弹性模量与使用常规技术对宏观样品获得的弹性模量相当。我们成功地证明了通过这种高度通用的技术开发的疏水性AFM吸头能够研究软物质的机械性能，这得益于减少的吸头相互作用以及定制的吸头形状和尺寸。

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