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首页> 外文期刊>NeuroImage >Age differences in brain systems supporting transient and sustained processes involved in prospective memory and working memory
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Age differences in brain systems supporting transient and sustained processes involved in prospective memory and working memory

机译：脑系统的年龄差异支持前瞻性记忆和工作记忆中涉及的短暂和持续过程

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In prospective memory (PM), an intention to act in response to an external event is formed, retained, and at a later stage, when the event occurs, the relevant action is performed. PM typically shows a decline in late adulthood, which might affect functions of daily living. The neural correlates of this decline are not well understood. Here, 15 young (6 female; age range = 23-30 years) and 16 older adults (5 female; age range = 64-74 years) were scanned with fMRI to examine age-related differences in brain activation associated with event-based PM using a task that facilitated the separation of transient and sustained components of PM. We show that older adults had reduced performance in conditions with high demands on prospective and working memory, while no age-difference was observed in low-demanding tasks. Across age groups, PM task performance activated separate sets of brain regions for transient and sustained responses. Age-differences in transient activation were found in fronto-striatal and MTL regions, with young adults showing more activation than older adults. Increased activation in young, compared to older adults, was also found for sustained PM activation in the IFG. These results provide new evidence that PM relies on dissociable transient and sustained cognitive processes, and that age-related deficits in PM can be explained by an inability to recruit PM-related brain networks in old age. (C) 2015 Elsevier Inc. All rights reserved.
机译：在前瞻性记忆（PM）中，形成，保留了响应外部事件采取行动的意图，并在以后的阶段（当事件发生时）执行相关动作。 PM通常显示出成年后期的减少，这可能会影响日常生活的功能。这种下降的神经相关性尚未得到很好的理解。在此，使用fMRI扫描了15位年轻（6位女性;年龄范围= 23-30岁）和16位成年人（5位女性;年龄范围= 64-74岁），以检查与事件相关的大脑激活相关的年龄相关差异PM使用有助于分离PM的瞬态和持续成分的任务。我们表明，在对前瞻性和工作记忆有很高要求的条件下，老年人的表现降低了，而在低要求的任务中没有观察到年龄差异。在各个年龄段中，PM任务执行都会激活单独的大脑区域集，以进行短暂和持续的响应。在额纹状体和MTL地区发现了瞬时激活的年龄差异，年轻人显示出比老年人更多的激活。与老年人相比，年轻人中激活的增加也被认为是IFG中持续性PM激活的原因。这些结果提供了新的证据，证明了PM依赖于可分离的短暂和持续的认知过程，并且与年龄相关的PM缺陷可以用在老年人中无法招募与PM相关的大脑网络来解释。 （C）2015 Elsevier Inc.保留所有权利。

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