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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Immunohistochemical localization of orexin/hypocretin-like immunoreactive peptides and melanin-concentrating hormone in the brain and pituitary of medaka.
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Immunohistochemical localization of orexin/hypocretin-like immunoreactive peptides and melanin-concentrating hormone in the brain and pituitary of medaka.

机译：甲草胺脑和垂体中食欲肽/促胰泌素样免疫反应性肽和黑色素浓缩激素的免疫组织化学定位。

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摘要

Orexin/hypocretin is a neuropeptide that is involved in the regulation of feeding behavior and the sleep-wakefulness cycle in mammals. Melanin-concentrating hormone (MCH) is believed to be another candidate involved in food intake in teleost fish as well. Thus, it is interesting to examine whether neural connections exist between the neurons producing these two hormones. We first examined the localization of orexin-like immunoreactivity (orexin-LI) in the brain of the medaka Oryzias latipes by using immunohistochemistry. We further examined the interaction between the orexin and MCH neurons in the medaka brain by performing double-staining immunohistochemistry. Orexin-LI cell bodies were located in the nucleus posterioris periventricularis (NPPv) of the hypothalamus, and orexin-LI fibers were detected not only in the hypothalamus but also extensively throughout the brain. Some orexin-LI fibers were in close contact with the MCH-immunoreactive (ir) cell bodies in the hypothalamus, as revealed by double-staining immunohistochemistry. Moreover, a few MCH-ir fibers were in close contact with the orexin-LI cell bodies. These results suggest that in the medaka brain, orexin performs various functions, including neuromodulation, and that neural connections exist between the orexin and MCH neurons.
机译：Orexin / hypocretin是一种神经肽，参与哺乳动物的进食行为和睡眠-觉醒周期的调节。人们认为，黑色素浓缩激素（MCH）也是硬骨鱼食物摄入的另一种候选物。因此，有趣的是检查在产生这两种激素的神经元之间是否存在神经联系。我们首先通过免疫组织化学检查了Medaka Oryzias latipes脑中orexin样免疫反应性（orexin-LI）的定位。我们通过进行双染色免疫组织化学进一步检查了甲aka脑中食欲肽和MCH神经元之间的相互作用。 Orexin-LI细胞体位于下丘脑的后脑室核（NPPv）中，不仅在下丘脑中而且在整个大脑中都检测到了Orexin-LI纤维。如双重染色免疫组织化学所揭示的，一些orexin-LI纤维与下丘脑中的MCH免疫反应（ir）细胞体紧密接触。此外，一些MCH-ir纤维与orexin-LI细胞体紧密接触。这些结果表明，在青aka脑中，食欲肽执行各种功能，包括神经调节，并且食欲肽和MCH神经元之间存在神经联系。

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