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首页> 外文期刊>Fisheries science >Interaction of orexin/hypocretin-like immunoreactive neurons with melanin-concentrating hormone and α-melanocyte-stimulating hormone neurons in brain of a pleuronectiform fish, barfin flounder
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Interaction of orexin/hypocretin-like immunoreactive neurons with melanin-concentrating hormone and α-melanocyte-stimulating hormone neurons in brain of a pleuronectiform fish, barfin flounder

机译：食欲素/ hypocretin样免疫反应性神经元与胸膜鳞状鱼类，鳍鳍比目鱼脑中黑色素浓缩激素和α-黑色素细胞刺激激素神经元的相互作用

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Immunohistochemical localization of orexin/hypocretin in the brain of a pleuronectiform fish, the barfin flounder Verasper moseri was examined as the first step in unraveling the possible function of the hormone in the brain. Orexin-A-like immunoreactive (ir) cell bodies were found to be located in the nucleus posterioris periventricularis (NPPv) of the hypothalamus, and orexin-A-like-ir fibers were detected not only in the hypothalamus but also extensively throughout the brain. The orexin-A-like-ir cell bodies did not project their fibers to the pituitary gland. Since melaninconcentrating hormone (MCH) and α-melanocyte-stimulating hormone (α-MSH) are suggested to regulate food intake in addition to orexin/hypocretin in the teleost fish, it was examined whether neural connections exist between orexin neurons and the MCH and α-MSH neurons in the barfin flounder brain by using double-staining immunohistochemistry. Some orexin-A-like-ir fibers were in close contact with the MCH-ir and α-MSH-ir cell bodies in the hypothalamus. Moreover, a few MCH-ir and α-MSH-ir fibers were in close contact with the orexin-A-like-ir cell bodies in the hypothalamus. These results suggest that reciprocal connections exist between the orexin and MCH neurons and between the orexin and α-MSH neurons in the brain of the barfin flounder.
机译：食欲素/ hypocretin在胸膜肺鱼脑中的免疫组织化学定位，被检验为条形比目鱼Verasper moseri，是揭示脑中激素可能功能的第一步。发现Orexin-A样免疫反应性（ir）细胞体位于下丘脑的后脑室核（NPPv）中，不仅在下丘脑中而且在整个大脑中均检测到Orexin-A样ir纤维。 。食欲素A样ir细胞体未将其纤维投射至垂体。由于建议在硬骨鱼中除了富含orexin / hypocretin以外，还建议使用黑色素浓缩激素（MCH）和α-黑色素细胞刺激激素（α-MSH）来调节食物摄入，因此我们检查了orexin神经元与MCH和α之间是否存在神经联系。 Barfin比目鱼脑中的-MSH神经元通过使用双染色免疫组织化学进行检测。一些orexin-A-like-ir纤维与下丘脑中的MCH-ir和α-MSH-ir细胞体紧密接触。此外，一些MCH-ir和α-MSH-ir纤维与下丘脑中的orexin-A-like-ir细胞体紧密接触。这些结果表明，在barfin比目鱼的脑中，食欲素和MCH神经元之间以及食欲素和α-MSH神经元之间存在相互联系。

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