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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >A cerebral functional imaging study by positron emission tomography in healthy volunteers receiving true or sham acupuncture needling
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A cerebral functional imaging study by positron emission tomography in healthy volunteers receiving true or sham acupuncture needling

机译：通过正电子发射断层扫描对接受真针刺或假针刺的健康志愿者进行的脑功能成像研究

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Our recent studies have demonstrated that needling in Baihui, Shuigou and Shenmen enhances glucose metabolism in the frontal lobes, thalamus, temporal lobe, and the lentiform nucleus in vascular dementia. This study examined the effect of true, sham and overt needling in Waiguan (TE5) on cerebral changes by positron emission tomography (PET) technique. Eighteen healthy volunteers were randomized to receive overt control, true or sham needling therapy. To manipulate true needling, a needle was inserted into 15 +-2mm into Waiguan and "deqi" was achieved by proper needle manipulation. For sham needling, needles with a blunt tip were pushed against the skin as the shaft moved into the handle, giving an illusion of insertion. For overt placebo, blunt needles were used and subjects did not receive any needling penetration. The tracer used was ~18fluoride-deoxygluocse. PET images obtained were processed and analyzed by the SPM2 software. Compared with overt needling, brain areas BA7,13,18,19, 21, 22, 27, 38, 40, 42 and 45 in Waiguan true needling group were significantly activated and areas BA4, 6, 7,19, 22 and 41 in sham needling group showed obvious activation. Compared to sham needling group, marked activation points were found in the areas of BA13 and 42 and left cerebellum in true needling group. Our study revealed a marked difference in brain metabolic changes between true and sham needling in Waiguan. Further studies are needed to explore the cerebral changes in patients with acupuncture and the pathological implications
机译：我们最近的研究表明，在百会，水沟和神门地区进行针刺可增强血管性痴呆的额叶，丘脑，颞叶和半形核的葡萄糖代谢。这项研究通过正电子发射断层扫描（PET）技术检查了外关中的真针，假针和明显针刺（TE5）对脑部变化的影响。 18名健康志愿者被随机分配接受公开对照，真针刺或假针刺治疗。为了进行真正的针刺，将针头插入外关的15 + -2mm处，并通过适当的针刺操作获得“ deqi”。对于假针刺，当刀柄移至手柄中时，将针尖钝的针抵在皮肤上，从而产生插入的错觉。对于明显的安慰剂，使用钝针，受试者未接受任何针刺。使用的示踪剂是〜18氟化物-脱氧葡糖酶。通过SPM2软件对获得的PET图像进行处理和分析。与明显的针刺相比，外关真正针刺组的脑区域BA7、13、18、19、21、22、27、38、40、42和45被显着激活，而脑针区域BA4、6、7、19、22和41假针刺组显示明显激活。与假针刺组相比，在真正的针刺组中，BA13和42以及左小脑的激活点明显。我们的研究显示外关中的真针刺和假针刺之间的大脑代谢变化存在明显差异。需要进一步研究以探索针灸患者的脑部变化及其病理意义

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