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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >HYPOTHERMIA PROTECTS AGAINST OXYGEN-GLUCOSE DEPRIVATION-INDUCED NEURONAL INJURY BY DOWN-REGULATING THE REVERSE TRANSPORT OF GLUTAMATE BY ASTROCYTES AS MEDIATED BY NEURONS
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HYPOTHERMIA PROTECTS AGAINST OXYGEN-GLUCOSE DEPRIVATION-INDUCED NEURONAL INJURY BY DOWN-REGULATING THE REVERSE TRANSPORT OF GLUTAMATE BY ASTROCYTES AS MEDIATED BY NEURONS

机译：体温过低通过下调神经元介导的星形胶质细胞逆转谷氨酸的转运，从而防止氧葡萄糖引起的神经损伤。

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Since hypothermia has been shown to protect the brain, therapeutic hypothermia has been extensively studied as a means to provide protection from cerebral ischemia (Akula et al.2012; Blanco et al.2012; Campos et al2012). For example, Busto and colleagues (Busto et al., 1987) previously demonstrated that even slight decreases in body temperature can prevent neuron death. However, the contribution of neuron protection to stroke therapy has yet to be established. It is hypothesized that the underlying temperature-sensitive mechanisms that mediate the progression of ischemic tissue may represent targets in the treatment of stroke. Previously published studies (Castillo, 1999; Castellanos et al., 2008) have indicated that the most critical mechanism that affects temperature-related damage is glutamate excitotoxicity.
机译：由于低温已被证明可以保护大脑，因此对低温治疗已作了广泛研究，以提供保护免受脑缺血的作用（Akula等，2012; Blanco等，2012; Campos等，2012）。例如，Busto及其同事（Busto等人，1987年）先前证明，即使体温略微降低也可以预防神经元死亡。然而，神经元保护对中风治疗的贡献尚未确定。假设介导缺血组织进展的潜在温度敏感性机制可能代表中风的治疗靶标。先前发表的研究（Castillo，1999; Castellanos等，2008）表明，影响温度相关损害的最关键机制是谷氨酸的兴奋性毒性。

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