首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >INTER-RELATIONSHIPS AMONG DIET, OBESITY AND HIPPOCAMPAL-DEPENDENT COGNITIVE FUNCTION
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INTER-RELATIONSHIPS AMONG DIET, OBESITY AND HIPPOCAMPAL-DEPENDENT COGNITIVE FUNCTION

机译:饮食,肥胖与海马依赖认知功能之间的相互关系

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摘要

Intake of a Western diet (WD), which is high in saturated fat and sugar, is associated with deficits in hippo-campal-dependent learning and memory processes as well as with markers of hippocampal pathology. In the present study, rats were trained to asymptote on hippocampal-dependent serial feature negative (FN) and hippocampal-independent simple discrimination problems. Performance was then assessed following 7 days on ad libitum chow and after 10, 24, 40, 60, and 90 days of maintenance on WD, on ketogenic (KETO) diet, which is high in saturated fat and low in sugar and other carbohydrates, or continued maintenance on chow (CHOW). Confirming and extending previous findings, diet-induced obese (DIO) rats fed WD showed impaired FN performance, increased blood-brain barrier (BBB) permeability, and increased fasting blood glucose levels compared to CHOW controls and to diet-resistant (DR) rats that did not become obese when maintained on WD.
机译:摄入富含饱和脂肪和糖的西方饮食(WD)与海马依赖于学习和记忆的过程的缺陷以及海马病理学的标记有关。在本研究中,对大鼠进行了训练以使其在依赖海马的连续特征阴性(FN)和与海马无关的简单歧视问题上渐近渐近。然后,在随意饮食7天后,在维持WD 10、24、40、60和90天后,在生酮饮食(KETO)上评估其性能,该饮食富含饱和脂肪,糖和其他碳水化合物含量低,或继续维护食物(CHOW)。证实并扩展了先前的发现,与CHOW对照和饮食抵抗性(DR)大鼠相比,以WD饮食喂养的肥胖(DIO)大鼠表现出FN性能受损,血脑屏障(BBB)渗透性增加和空腹血糖水平升高保持WD时不会变胖。

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