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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >PREFRONTAL D1 DOPAMINE SIGNALING IS NECESSARY FOR TEMPORAL EXPECTATION DURING REACTION TIME PERFORMANCE
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PREFRONTAL D1 DOPAMINE SIGNALING IS NECESSARY FOR TEMPORAL EXPECTATION DURING REACTION TIME PERFORMANCE

机译：反应时间性能期间，需要临时的D1多巴胺信号指示

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摘要

Responses during a simple reaction time task are influenced by temporal expectation, or the ability to anticipate when a stimulus occurs in time. Here, we test the hypothesis that prefrontal D1 dopamine signaling is necessary for temporal expectation during simple reaction time task performance. We depleted dopamine projections to the medial prefrontal circuits by infusing 6-hydroxidop-amine, a selective neurotoxin, into the ventral tegmental area (VTA) of rats, and studied their performance on a simple reaction time task with two delays. VTA dopamine depletion did not change movements or learning of the reaction time task. However, VTA dopamine-depleted animals did not develop delay-dependent speeding of reaction times, suggesting that mesocortical dopamine signaling is required for temporal expectation. Next, we manipulated dopamine signaling within the medial prefrontal cortex using local pharmacology. We found that SCH23390, a D1-type dopamine receptor antagonist, specifically attenuated delay-dependent speeding, while sulpiride, a D2-type receptor antagonist, did not. These data suggest that prefrontal D1 dopamine signaling is necessary for temporal expectation during performance of a simple reaction time task. Our findings provide insight into temporal processing of the prefrontal cortex, and how dopamine signaling influences prefrontal circuits that guide goal-directed behavior.
机译：在简单的反应时间任务中的反应受时间预期或预期刺激何时及时发生的能力的影响。在这里，我们测试的假设是前额叶D1多巴胺信号传导对于简单反应时间任务执行过程中的时间期望是必要的。我们通过向大鼠腹侧被盖区（VTA）注入6-羟氧化胺（一种选择性的神经毒素），将多巴胺投射到内侧前额叶回路中，并研究了它们在简单的反应时间任务上的表现（有两个延迟）。 VTA多巴胺的消耗并没有改变动作或反应时间任务的学习。但是，VTA消耗多巴胺的动物并未出现延迟依赖性的反应时间加快，这表明中皮皮质的多巴胺信号传导是暂时预期所必需的。接下来，我们使用局部药理学在前额内侧皮层内操纵多巴胺信号传导。我们发现D23型D1型多巴胺受体拮抗剂SCH23390特异性地减弱了延迟依赖性速度，而D2型受体Sulpiride则没有。这些数据表明，前额叶D1多巴胺信号传导对于执行简单反应时间任务期间的时间期望是必要的。我们的发现为前额叶皮层的时间处理以及多巴胺信号传导如何影响指导目标定向行为的前额叶回路提供了见识。

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