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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >SPLIT-BELT LOCOMOTION IN PARKINSON'S DISEASE WITH AND WITHOUT FREEZING OF GAIT
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SPLIT-BELT LOCOMOTION IN PARKINSON'S DISEASE WITH AND WITHOUT FREEZING OF GAIT

机译：带和不带步态冻结的帕金森氏病中的皮带运动

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Background: Parkinson's disease (PD) patients have an increased gait asymmetry and variability, which is most pronounced in patients with freezing of gait (FOG). We examined if stride time variability and deficits in inter-limb coordination between the upper and lower limbs would increase during split-belt locomotion in PD, and particularly so in patients with FOG. Methods: Fourteen PD patients (seven with FOG, matched for disease severity with the seven non-freezers) and 10 healthy controls walked on a treadmill with split belts at different speeds (2 versus 3 km/h). Gait was recorded by means of a video motion analysis system. Outcome measures were stride length asymmetry and variability, stride time asymmetry and variability, ipsilateral and contralateral interlimb coordination, and phase coordination index. Results: Both PD subjects and controls were able to adapt to split-belt walking by modulating their stride length. However, freezers showed a larger increase in stride time asymmetry and stride time variability due to split-belt walking compared to non-freezers. Furthermore, contralateral inter limb coordination improved in control subjects during split-belt walking, but not in PD patients (freezers and non-freezers). Phase coordination index did not change differently across the three groups. Conclusions: The ability to walk under split-belt conditions was preserved in PD. Non-freezers and controls compensated for the experimentally increased stride length asymmetry by decreasing their stride time asymmetry. This ability was lost in freezers, who in fact Increased their stride time asymmetry during split-belt walking. As a result, stride time variability also increased in freezers. These findings support the hypothesis that FOG is related to gait asymmetries and to gait timing deficits.
机译：背景：帕金森病（PD）患者的步态不对称性和变异性增加，这在步态冻结（FOG）的患者中最为明显。我们检查了PD尤其是FOG患者在劈开皮带运动期间步幅的时间变异性和上，下肢之间的肢体协调不足是否会增加。方法：14名PD患者（其中7名患有FOG，与7种非冰柜相匹配的疾病严重程度）和10名健康对照者以不同的速度在皮带分离的跑步机上行走（2 vs 3 km / h）。通过视频运动分析系统记录步态。结果指标为步长不对称性和变异性，步长时间不对称性和变异性，同侧和对侧肢体协调以及相协调指数。结果：PD受试者和对照组都能够通过调节步幅长度来适应皮带式步行。然而，与非冷冻机相比，由于分开皮带行走，冷冻机的步幅时间不对称性和步幅时间可变性增加幅度更大。此外，在劈开皮带的步行过程中，控制对象的对侧肢体协调性得到了改善，但PD患者（冷冻室和非冷冻室）则没有。在三组中，相协调指数没有变化。结论：PD保留了在分开腰带条件下行走的能力。非冷冻机和控件通过减小步幅时间不对称性来补偿实验上增加的步幅不对称性。冰柜失去了这种能力，事实上，冰柜在劈开皮带时会增加步幅时间的不对称性。结果，冷冻机的步幅时间可变性也增加了。这些发现支持以下假设：FOG与步态不对称和步态时间缺陷有关。

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