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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >CANNABINOID AND OPIOID INTERACTIONS: IMPLICATIONS FOR OPIATE DEPENDENCE AND WITHDRAWAL
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CANNABINOID AND OPIOID INTERACTIONS: IMPLICATIONS FOR OPIATE DEPENDENCE AND WITHDRAWAL

机译：大麻素和阿片类药物的相互作用：对阿片依赖和戒断的影响

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Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and emotional symptoms. High rates of relapse and limited treatment success rates for opiate addiction have prompted a search for new approaches. For many opiate addicts, achieving abstinence may be further complicated by poly-drug use and co-morbid mental disorders. Research over the past decade has shed light on the influence of endocannabinoids (ECs) on the opioid system. Evidence from both animal and clinical studies point toward an interaction between these two systems, and suggest that targeting the EC system may provide novel interventions for managing opiate dependence and withdrawal. This review will summarize the literature surrounding the molecular effects of cannabinoids and opioids on the locus coeruleus-norepinephrine system, a key circuit implicated in the negative sequelae of opiate addiction. A consideration of the trends and effects of marijuana use in those seeking treatment to abstain from opiates in the clinical setting will also be presented. In summary, the present review details how cannabinoid-opioid interactions may inform novel interventions in the management of opiate dependence and withdrawal.
机译：从诸如海洛因或口服麻醉药之类的阿片类药物中撤药的特征是有许多厌恶的身体和情绪症状。阿片成瘾的高复发率和有限的治疗成功率促使人们寻求新方法。对于许多鸦片上瘾者来说，禁忌可能会因为使用多种药物和合并精神疾病而变得更加复杂。过去十年的研究揭示了内源性大麻素（EC）对阿片类药物系统的影响。来自动物和临床研究的证据都指向这两个系统之间的相互作用，并表明以EC系统为目标可能为管理鸦片依赖和戒断提供了新颖的干预措施。这篇综述将总结有关大麻素和阿片类药物对蓝斑脑-去甲肾上腺素基因位点的分子作用的文献，该位点可能与鸦片成瘾的负面后遗症有关。在临床环境中，还将对寻求治疗以戒除鸦片的人使用大麻的趋势和影响进行考虑。总而言之，本综述详细介绍了大麻素与阿片类药物的相互作用如何为鸦片依赖性和戒断治疗提供新的干预手段。

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