Overexpression of NAD(P)H: quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones

Glorieux Christophe; Sandoval Juan Marcelo; Dejeans Nicolas; Ameye Genevieve; Poirel Helene Antoine; Verrax Julien; Buc Calderon Pedro

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Overexpression of NAD(P)H: quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones

机译：NAD（P）H：醌氧化还原酶1（NQO1）的过表达和NQO1基因座的基因组增益调节乳腺癌细胞对醌的敏感性

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Aims: Alterations in the expression of antioxidant enzymes are associated with changes in cancer cell sensitivity to chemotherapeutic drugs (menadione and beta-lapachone). Mechanisms of acquisition of resistance to pro-oxidant drugs were investigated using a model of oxidative stress-resistant MCF-7 breast cancer cells (Resox cells).

机译：目的：抗氧化酶表达的改变与癌细胞对化疗药物（甲萘醌和β-拉帕酮）的敏感性变化有关。使用抗氧化应激的MCF-7乳腺癌细胞（Resox细胞）模型研究了对抗氧化药物产生抗性的机制。

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《Life sciences》 |2016年第1期|共9页
作者
Glorieux Christophe; Sandoval Juan Marcelo; Dejeans Nicolas; Ameye Genevieve; Poirel Helene Antoine; Verrax Julien; Buc Calderon Pedro;
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正文语种 eng
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NQO1; Breast cancer cells; Genomic gain; Menadione; beta-Lapachone; Redox alterations;

机译：NQO1;乳腺癌细胞;基因组增益;甲萘醌;β-拉帕酮;氧化还原改变;

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1. Overexpression of NAD(P)H: quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones [J] . Glorieux Christophe, Sandoval Juan Marcelo, Dejeans Nicolas, Life sciences . 2016,第1期

机译：NAD（P）H：醌氧化还原酶1（NQO1）的过表达和NQO1基因座的基因组增益调节乳腺癌细胞对醌的敏感性
2. NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones [J] . SiegelD., YanC., RossD. Biochemical Pharmacology . 2012,第8期

机译：NAD（P）H：醌氧化还原酶1（NQO1）在抗肿瘤醌的敏感性和抗性中
3. The natural compound ascorbigen modulates NADPH-quinone oxidoreductase (NQO1) mRNA and enzyme activity levels in cultured liver cells and in laboratory rats [J] . Wagner AE, Hug H, Gossl R, Annals of Nutrition & Metabolism . 2008,第2期

机译：天然化合物抗坏血酸调节培养的肝细胞和实验大鼠中的NADPH-醌氧化还原酶（NQO1）mRNA和酶活性水平
4. Upregulation of NAD(P)H:Quinone Oxidoreductase (NQO1) in Glial Cells of 6-Hydroxydopamine-Lesioned Substantia Nigra in the Rat [C] . Andrea C. Kil, Benjamin Drukarch, Allert J. Jonker, Triennial Meeting of the International Basal Ganglia Society . 2009

机译：NAD（P）H：醌氧化还原酶（NQO1）在大鼠6-羟基多胺 - 损伤的胶质细胞中的喹啉氧化还原酶（NQO1）
5. Benzene-metabolite-induced apoptosis: Implications of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism for susceptibility of hematopoietic cells to phenolic metabolites [D] . Moran, Julie L. 1999

机译：苯代谢物诱导的细胞凋亡：NAD（P）H：醌氧化还原酶1（NQO1）C609T多态性对造血细胞对酚类代谢物的敏感性的影响
6. NAD(P)H:Quinone Oxidoreductase 1 (NQO1) in the Sensitivity and Resistance to Antitumor Quinones [O] . David Siegel, Chao Yan, David Ross -1

机译：NaD（p）H：醌氧化还原酶-1（NQO1）的敏感性和耐药性对醌抗肿瘤
7. Development of Indolequinone Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1): NQO1 Inhibition and Growth Inhibitory Activity in Human Pancreatic MIA PaCa-2 Cancer Cells [O] . -1

机译：NAD（P）H：醌氧化还原酶1（NQO1）：NQO1抑制和生长抑制活性的吲哚醌机理抑制剂：人胰腺MIA-2癌细胞中的抑制和生长抑制活性

Overexpression of NAD(P)H: quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones

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