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PEGylated CsxWO3 nanorods as an efficient and stable 915 nm-laser-driven photothermal agent against cancer cells

机译：聚乙二醇化的CsxWO3纳米棒作为针对癌细胞的高效稳定的915 nm激光驱动的光热剂

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摘要

WO3-x nanomaterials have been demonstrated to be one kind of efficient near-infrared (NIR) laser-driven photothermal nanoagents, but their photothermal stability is still unsatisfied. In addition, a 980 nm laser is usually used as NIR light source, but it has an overheating effect due to optical absorption of water and biological specimens. To address these problems, we have prepared PEGylated Cs-doped WO3 (CsxWO3) nanorods by a solvothermal synthesis-PEGylation two-step route. CsxWO3 nanorods have diameters of similar to 11 nm and lengths of similar to 50 nm, and they exhibit increased absorption in the NIR region (700-1100 nm). With PEGylated CsxWO3 nanorods as the photothermal nanoagent, we compare the overheating and penetration effects of 915 and 980 nm lasers as NIR light sources. Compared with the 980 nm laser, the 915 nm laser provides drastically less overheating of water, and higher penetration ability of water/skin due to quite low water absorption. Importantly, under the irradiation of a 915 nm laser, CsxWO3 nanorods exhibit excellent photothermal conversion performance with high stability. Furthermore, by the photothermal effect of PEGylated CsxWO3 nanorods, in vivo cancer cells can be efficiently destroyed under the irradiation of a 915 nm laser. Therefore, PEGylated CsxWO3 nanorods can be used as a promising efficient and stable NIR-laser-driven photothermal agent against in vivo cancer cells.
机译：WO3-x纳米材料已被证明是一种有效的近红外（NIR）激光驱动的光热纳米剂，但其光热稳定性仍不令人满意。此外，通常使用980 nm激光作为近红外光源，但是由于对水和生物样本的光吸收，它具有过热的作用。为了解决这些问题，我们通过溶剂热合成-PEG化两步法制备了聚乙二醇化的掺Cs的WO3（CsxWO3）纳米棒。 CsxWO3纳米棒的直径近似于11 nm，长度近似于50 nm，并且它们在NIR区域（700-1100 nm）中显示出增加的吸收。以聚乙二醇化的CsxWO3纳米棒为光热纳米剂，我们比较了915和980 nm激光器作为近红外光源的过热和穿透效应。与980 nm激光器相比，915 nm激光器提供了极少的水过热，并且由于极低的吸水率而具有更高的水/皮肤穿透能力。重要的是，在915 nm激光的照射下，CsxWO3纳米棒具有出色的光热转换性能和高稳定性。此外，通过PEG化的CsxWO3纳米棒的光热效应，可以在915nm激光的照射下有效地破坏体内癌细胞。因此，聚乙二醇化的CsxWO3纳米棒可用作针对体内癌细胞的有前途的高效且稳定的近红外激光驱动的光热剂。

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