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Solid lipid nanoparticles (SLNs): delivery vehicles for food bioactives

机译：固体脂质纳米颗粒（SLN）：用于食品生物活性物质的输送工具

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摘要

Bioactives which are isolated from different sources like plants, animals, etc. are known to be ideal candidates to treat and prevent chronic health problems such as obesity, hypertension, cardiovascular diseases, cancer, etc. Unfortunately, due to changes in life style and food habits, humans are consuming fewer healthy bioactives than recommended. Hence there is an increasing demand from consumers for food products which are fortified with these bioactives. However, addition of these healthy bioactives to food products for fortification is a challenging job. The main cause is their susceptibility to a complex matrix present in the food product and gastro intestinal tract (GIT) such as pH, temperature, enzymes, etc. Though colossal effort has been made by researchers to successfully translate drug delivery technology for bioactives delivery to protect these susceptible bioactives during production, storage and consumption, success is limited. Due to their near impeccable suitability for the delivery of bioactives in terms of toxicity, scalability, acceptability, solid lipid nanoparticles (SLNs) are drawing attention from food technologists. In this review, effort has been made to present an overview about expectations and suitability of SLNs for delivery of bioactives, selection of the ingredients and their importance in achieving those expectations and an industrially feasible methodology for production of SLNs.
机译：从植物，动物等不同来源分离出的生物活性物质是治疗和预防肥胖，高血压，心血管疾病，癌症等慢性健康问题的理想候选者。不幸的是，由于生活方式和食物的变化习惯，人类消耗的健康生物活性物质少于建议的摄入量。因此，消费者对用这些生物活性物质强化的食品的需求不断增加。但是，将这些健康的生物活性物质添加到食品中进行强化是一项艰巨的任务。主要原因是它们对食品和胃肠道（GIT）中存在的复杂基质的敏感性，例如pH，温度，酶等。尽管研究人员做出了巨大的努力，成功地将药物递送技术转化为生物活性物质的递送至在生产，储存和消费过程中保护这些易感生物活性物质，成功是有限的。由于它们在毒性，可扩展性，可接受性方面对生物活性物质的传递几乎无可挑剔的适用性，固体脂质纳米颗粒（SLN）引起了食品技术人员的关注。在这篇综述中，我们努力提出了关于SLNs对生物活性物质的输送的期望和适用性，成分的选择及其在实现这些期望中的重要性的概述，以及在工业上可行的生产SLNs的方法。

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