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首页> 外文期刊>BioArchitecture >Aged skeletal muscle retains the ability to fully regenerate functional architecture.
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Aged skeletal muscle retains the ability to fully regenerate functional architecture.

机译：老年骨骼肌保留了完全再生功能结构的能力。

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While the general understanding of muscle regenerative capacity is that it declines with increasing age due to impairments in the number of muscle progenitor cells and interaction with their niche, studies vary in their model of choice, indices of myogenic repair, muscle of interest and duration of studies. We focused on the net outcome of regeneration, functional architecture, compared across three models of acute muscle injury to test the hypothesis that satellite cells maintain their capacity for effective myogenic regeneration with age. Muscle regeneration in extensor digitorum longus muscle (EDL) of young (3 mo-old), old (22 mo-old) and senescent female mice (28 mo-old) was evaluated for architectural features, fiber number and central nucleation, weight, collagen and fat deposition. The 3 injury paradigms were: a myotoxin (notexin) which leaves the blood vessels and nerves intact, freezing (FI) that damages local muscle, nerve and blood vessels and denervation-devascularization (DD) which dissociates the nerves and blood vessels from the whole muscle. Histological analyses revealed successful architectural regeneration following notexin injury with negligible fibrosis and fully restored function, regardless of age. In comparison, the regenerative response to injuries that damaged the neurovascular supply (FI and DD) was less effective, but similar across the ages. The focus on net regenerative outcome demonstrated that old and senescent muscle has a robust capacity to regenerate functional architecture.
机译：尽管人们对肌肉再生能力的普遍理解是，由于肌肉祖细胞数量的减少以及与自身生态位的相互作用，肌肉再生能力会随着年龄的增长而下降，但研究的选择模型，成肌修复指标，感兴趣的肌肉和持续时间却有所不同。学习。我们将再生的最终结果，功能结构与三种急性肌肉损伤模型进行了比较，以检验卫星细胞保持其随着年龄增长进行有效肌原性再生的能力这一假设。评估了年轻（3月龄），老龄（22月龄）和衰老雌性小鼠（28月龄）的指趾伸肌（EDL）的肌肉再生的结构特征，纤维数量和中央成核，体重，胶原蛋白和脂肪沉积。 3种损伤范例是：肌肉毒素（notexin）使血管和神经完好无损;冰冻（FI）破坏局部肌肉，神经和血管;去神经-去血管化（DD）使神经和血管与整体分离肌肉。组织学分析表明，Notexin损伤后可成功进行建筑更新，纤维化程度可忽略不计，并且功能完全恢复，无论年龄大小。相比之下，对损伤神经血管供应（FI和DD）的损伤的再生反应效果较差，但在各个年龄段中相似。对净再生结果的关注表明，老年和衰老的肌肉具有强大的功能结构再生能力。

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