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Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom

机译:光学相干断层扫描点扩散函数与纳米粒子嵌入的幻影的三维表征

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摘要

We present a novel (to our knowledge) approach for measurement of the three-dimensional point spread function (PSF) of optical coherence tomography (OCT) systems using a nanoparticle-embedded phantom (NEP), toward development of standardized test methods for biophotonic imaging. The NEP comprises highly reflective plasmonic nanoparticles, homogeneously distributed in a transparent silicone matrix. OCT image volumes were analyzed to characterize PSFs in axial and lateral directions at a variety of locations in the NEP. Results indicate submicrometer agreement with conventional approaches to measure dimensions of the PSF. The NEP offers a robust approach for validating and comparing imaging performance of OCT devices.
机译:我们提出一种新颖的(据我们所知)方法,用于测量使用纳米粒子嵌入体模(NEP)的光学相干断层扫描(OCT)系统的三维点扩散函数(PSF),朝着开发生物光子成像标准测试方法的方向发展。 NEP包含均匀分布在透明有机硅基质中的高反射等离子体纳米颗粒。分析了OCT图像体积,以表征NEP中各个位置的轴向和横向PSF。结果表明亚微米级与常规方法可以测量PSF的尺寸。 NEP提供了一种强大的方法来验证和比较OCT设备的成像性能。

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