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首页> 外文期刊>Optics Letters >Compression of Born ratio for fluorescence molecular tomography/x-ray computed tomography hybrid imaging: methodology and in vivo validation
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Compression of Born ratio for fluorescence molecular tomography/x-ray computed tomography hybrid imaging: methodology and in vivo validation

机译:荧光分子层析成像/ x射线计算机层析成像混合成像的Born压缩:方法和体内验证

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摘要

The 360° rotation geometry of the hybrid fluorescence molecular tomography/x-ray computed tomography modality allows for acquisition of very large datasets, which pose numerical limitations on the reconstruction. We propose a compression method that takes advantage of the correlation of the Born-normalized signal among sources in spatially formed clusters to reduce the size of system model. The proposed method has been validated using an ex vivo study and an in vivo study of a nude mouse with a subcutaneous 4T1 tumor, with and without inclusion of a priori anatomical information. Compression rates of up to two orders of magnitude with minimum distortion of reconstruction have been demonstrated, resulting in large reduction in weight matrix size and reconstruction time.
机译:混合荧光分子层析成像/ x射线计算机层析成像模式的360°旋转几何形状允许采集非常大的数据集,这对重建造成了数值限制。我们提出一种压缩方法,该方法利用空间形成的簇中源之间的Born归一化信号的相关性来减小系统模型的大小。使用具有皮下4T1肿瘤的裸鼠的体外研究和体内研究,在有和没有先验解剖学信息的情况下,已经对提出的方法进行了验证。已经证明压缩率高达两个数量级,并且重建失真最小,从而导致重量矩阵大小和重建时间大大减少。

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