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Toward transduodenal diffuse optical tomography of proximal pancreas

机译:胰十二指肠近端经十二指肠弥漫性光学层析成像

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摘要

We demonstrate the feasibility of diffuse optical tomography (DOT) of the proximal pancreas by using optical applicator channels deployed longitudinally along the exterior surface of a duodenoscope. As the duodenum that nearly encircles the proximal pancreas forms a natural "C-loop" that is approximately three-quarters of a circle of 5-6 cm in diameter, a multichannel optical applicator attached to a duodenoscope has the potential to perform transduodenal DOT sampling of the bulk proximal pancreas wherein most cancers and many cystic lesions occur. The feasibility of transduodenal DOT is demonstrated on normal porcine pancreas tissues containing an introduced gelatinous inclusion of approximately 3 cm in diameter, by using nine source channels and six detector channels attached to a duodenoscope. Concurrent ultrasonography of the gelatinous inclusion in the porcine pancreas parenchyma provided a coarse, albeit indispensable, anatomic prior to transduodenal DOT in reconstructing a contrast of optical properties in the pancreas.
机译:我们通过使用沿十二指肠镜的外表面纵向部署的光学敷贴器通道,证明了近端胰腺弥漫性光学层析成像(DOT)的可行性。由于几乎环绕近端胰腺的十二指肠形成自然的“ C形环”,直径约为5-6厘米圆的四分之三,因此连接到十二指肠镜的多通道光学敷贴器有可能进行十二指肠DOT采样大部分癌症和许多囊性病变发生的大块近端胰腺。通过使用连接到十二指肠镜的九个源通道和六个检测器通道,在包含约3 cm直径引入的凝胶状包裹体的正常猪胰腺组织上证明了跨十二指肠DOT的可行性。在重建十二指肠DOT之前,猪胰腺实质中的凝胶状内含物的并发超声检查提供了一个粗糙的,尽管必不可少的解剖学信息。

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