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In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

机译:使用光谱光学相干断层扫描技术对小鼠模型中的烧伤进行体内分析

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摘要

Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.
机译:生物组织的光谱分析可以洞察由于疾病或伤害引起的结构和功能的变化。可以使用光学相干断层扫描(OCT)对组织成像进行深度分辨光谱测量。在此,光谱OCT被应用于小鼠模型中烧伤的体内测量。比较了数据处理和分析方法的准确性。发现对烧伤的组织进行分类的总体准确度高达91%,在接收器工作特性曲线的曲线下产生了0.97的面积。通过与组织病理学的相关性来识别光谱变化的起源。

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