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Probability density function formalism for optical coherence tomography signal analysis: a controlled phantom study

机译:光学相干断层扫描信号分析的概率密度函数形式主义:受控模型研究

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摘要

The distribution of backscattered intensities as described by the probability density function (PDF) of tissue-scattered light contains information that may be useful for tissue assessment and diagnosis, including characterization of its pathology. In this Letter, we examine the PDF description of the light scattering statistics in a well characterized tissue-like particulate medium using optical coherence tomography (OCT). It is shown that for low scatterer density, the governing statistics depart considerably from a Gaussian description and follow the K distribution for both OCT amplitude and intensity. The PDF formalism is shown to be independent of the scatterer flow conditions; this is expected from theory, and suggests robustness and motion independence of the OCT amplitude (and OCT intensity) PDF metrics in the context of potential biomedical applications. (C) 2016 Optical Society of America
机译:如组织散射光的概率密度函数(PDF)所述,反向散射强度的分布包含可能对组织评估和诊断有用的信息,包括其病理特征。在这封信中,我们使用光学相干断层扫描(OCT)检查了特征明确的组织状颗粒介质中光散射统计数据的PDF描述。结果表明,对于低散射体密度,控制统计量与高斯描述大相径庭,并且对于OCT振幅和强度都遵循K分布。 PDF形式主义被证明与散射流条件无关。这在理论上是可以预期的,并建议在潜在的生物医学应用程序中,OCT振幅(和OCT强度)PDF度量的鲁棒性和运动独立性。 (C)2016美国眼镜学会

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