Sub-diffuse optical biomarkers characterize localized microstructure and function of cortex and malignant tumor

Bravo Jaime J.; Paulsen Keith D.; Roberts David W.; Kanick Stephen C.

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Sub-diffuse optical biomarkers characterize localized microstructure and function of cortex and malignant tumor

机译：亚扩散光学生物标记物表征皮质和恶性肿瘤的局部微观结构和功能

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This study uses a sub-diffusive light transport model to analyze fiber-optic measurements of reflectance spectra to recover endogenous tissue biomarkers and to correct raw fluorescence emissions for distortions from background optical properties. Measurements in tissue-simulating phantoms validated accurate recovery of the reduced scattering coefficient [( 0.3-3.4 mm(-1)), error 10%], blood volume fraction [( 1-3 vol%), error 7%], and a dimensionless metric of anisotropic scattering,., that is sensitive to sub-millimeter tissue ultrastructure [(1.29-2.06), error 11%]. In vivo sub-diffusive optical data acquired during clinical neurosurgeries characterize differences in microstructure (gamma), perfusion (blood volume), and metabolism (PpIX fluorescence) between normal cortex and malignant tumor. (C) 2016 Optical Society of America

机译：这项研究使用亚扩散光传输模型来分析反射光谱的光纤测量结果，以恢复内源性组织生物标志物并校正原始荧光发射，以消除背景光学特性造成的畸变。在组织模拟体模中进行的测量验证了降低的散射系数[（0.3-3.4 mm（-1）），误差10％]，血容量分数[（1-3 vol％），误差7％]和a的准确恢复。各向异性散射的无量纲度量，对亚毫米组织超微结构敏感[（1.29-2.06），误差11％]。在临床神经外科手术期间获得的体内亚扩散光学数据表征了正常皮层和恶性肿瘤之间的微结构（γ），灌注（血容量）和新陈代谢（PpIX荧光）的差异。（C）2016美国眼镜学会

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《Optics Letters》 |2016年第4期|共4页
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Bravo Jaime J.; Paulsen Keith D.; Roberts David W.; Kanick Stephen C.;
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1. Sub-diffuse optical biomarkers characterize localized microstructure and function of cortex and malignant tumor [J] . Bravo Jaime J., Paulsen Keith D., Roberts David W., Optics Letters . 2016,第4期

机译：亚扩散光学生物标记物表征皮质和恶性肿瘤的局部微观结构和功能
2. Clinico-pathological correlation of ovarian tumors and tumor like lesions with role of CA125 and HE4 as biomarkers for discrimination of benign and malignant ovarian tumors [J] . Nidhi Verma, Vandana Tiwari, S. P. Sharma, International Journal of Research in Medical Sciences . 2018,第7期

机译：卵巢肿瘤和类瘤样病变的临床病理相关性与CA125和HE4作为鉴别卵巢良性和恶性肿瘤的生物标志物
3. Functional diffusion map of malignant brain tumors: A surrogate imaging biomarker for early prediction of therapeutic response and patient survival [J] . Basma Abdel Moneim Dessouky, Osama Lotfy El Abd, Ahmad Gaber El Gowily, The Egyptian Journal of Radiology and Nuclear Medicine . 2010,第3期

机译：恶性脑肿瘤的功能扩散图：替代成像生物标志物，可早期预测治疗反应和患者生存
4. A Multi-task Deep Learning Framework to Localize the Eloquent Cortex in Brain Tumor Patients Using Dynamic Functional Connectivity [C] . Naresh Nandakumar, Niharika Shimona DSouza, Komal Manzoor, International Conference on Medical Image Computing and Computer-Assisted Intervention;International Workshop on Machine Learning in Clinical Neuroimaging;Radiomics and Radiogenomics in Neuro-oncology using AI Conference . 2020

机译：一种多任务深度学习框架，以利用动态功能连通性本地化脑肿瘤患者的雄性皮质
5. Disparate Activation and Function of B Cells in Benign and Malignant Tumors of the Skin: Implications for Cancer Immunotherapy [D] . Podolsky, Michael Adam. 2017

机译：皮肤良性和恶性肿瘤中B细胞的不同激活和功能：对癌症免疫疗法的影响
6. Sub-diffuse optical biomarkers characterize localized microstructure and function of cortex and malignant tumor [O] . Jaime J. Bravo, Keith D. Paulsen, David W. Roberts, -1

机译：亚扩散光学生物标记物表征皮质和恶性肿瘤的局部微观结构和功能
7. Functional diffusion map of malignant brain tumors: A surrogate imaging biomarker for early prediction of therapeutic response and patient survival [O] . Dessouky Basma Abdel Moneim, El Abd Osama Lotfy, El Gowily Ahmad Gaber, 2010

机译：恶性脑肿瘤的功能扩散图：替代成像生物标志物，可早期预测治疗反应和患者生存
8. Ras-Directed N-Glycoproteins Are Novel Early Biomarkers for Tumorigenesis and Malignant Transformation and Therapeutic Targets of Neurofibromatosis Type 1. [R] . Zhu, Q. 2014

机译：Ras指导的N-糖蛋白是用于肿瘤发生和恶性转化的新型早期生物标志物和1型神经纤维瘤病的治疗靶点。

Sub-diffuse optical biomarkers characterize localized microstructure and function of cortex and malignant tumor

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