...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Organometallics >Disila-Phantolide and Derivatives: Synthesis and Olfactory Characterization of Silicon-Containing Derivatives of the Musk Odorant Phantolide
【24h】

Disila-Phantolide and Derivatives: Synthesis and Olfactory Characterization of Silicon-Containing Derivatives of the Musk Odorant Phantolide

机译：Disila-Phantolide及其衍生物：麝香气味Phantolide的含硅衍生物的合成和嗅觉表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

1-(1,1,2,3,3,6-Hexamethyl-1,3-disilaindan-5-yl)ethanone (disila-phantolide, 4), a disila-analogue of the musk odorant phantolide (3), and its silicon-containing derivatives 5-13 were prepared in multistep syntheses and studied for their olfactory properties. In addition, 7 and 11 were structurally characterized by single-crystal X-ray diffraction, and compounds 4-13 were studied computationally (calculations of minimum-energy conformers and the electrostatic potentials). Compounds 4-13 differ in their Si-X-Si moiety (X = CHMe, C=CH2, CH2, O, cyclopropane-1,1-diyl) and in an optional C-6 methyl substituent on the 1,3-disilaindane skeleton. Disila-phantolide (4, X = CHMe), the methylene derivatives 6 and 7 (X = C=CH2), and the cyclopropane-1, 1-diyl derivatives 12 and 13 (X = cyclopropane-1,1-diyl) are new musk odorants, with 6 and 7 being the most interesting and powerful ones. In contrast, compounds 8 and 9 (X = CH2) as well as 10 and 11 (X = O) were found to be very weak to odorless and devoid of any musk character.
机译：1-（1,1,2,3,3,6-六甲基-1,3-二硅萘丹-5-基）乙酮（disila-phantolide，4），麝香气味的邻苯二酚（3）的diila-alogue，和它的含硅衍生物5-13是通过多步合成制备的，并对其嗅觉特性进行了研究。此外，通过单晶X射线衍射对7和11进行了结构表征，并对化合物4-13进行了计算研究（最小能量构象异构体和静电势的计算）。化合物4-13的Si-X-Si部分不同（X = CHMe，C = CH2，CH2，O，环丙烷-1,1-二基）和1,3-二硅氢化茚上的可选C-6甲基取代基骨架。二硅-甲基苯甲内酯（4，X = CHMe），亚甲基衍生物6和7（X = C = CH2），以及环丙烷-1、1-二基衍生物12和13（X =环丙烷-1,1-二基）新的麝香加味剂，其中6和7是最有趣且功能最强大的。相反，发现化合物8和9（X = CH2）以及化合物10和11（X = O）非常弱，无味，没有麝香。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号