Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke

Santos Emilie M. M.; Dankbaar Jan Willem; Treurniet Kilian M.; Horsch Alexander D.; Roos Yvo B.; Kappelle L. Jaap; Niessen Wiro J.; Majoie Charles B.; Velthuis Birgitta; Marquering Henk A.

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Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke

机译：渗透性血栓与急性缺血性卒中患者较高的静脉重组组织型纤溶酶原激活剂治疗成功相关

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Background and Purpose-Preclinical studies showed that thrombus permeability improves recombinant tissue-type plasminogen activator (r-tPA) efficacy. We hypothesize that thrombus permeability estimated from radiological imaging is associated with improved recanalization after treatment with intravenously administered r-tPA (r-tPA) and with better functional outcome.

机译：背景和目的临床前研究表明，血栓通透性提高了重组组织型纤溶酶原激活剂（r-tPA）的功效。我们假设从放射影像学估计的血栓通透性与静脉给予r-tPA（r-tPA）治疗后的再通改善和功能改善有关。

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《Stroke: A Journal of Cerebral Circulation》 |2016年第8期|共8页
作者
Santos Emilie M. M.; Dankbaar Jan Willem; Treurniet Kilian M.; Horsch Alexander D.; Roos Yvo B.; Kappelle L. Jaap; Niessen Wiro J.; Majoie Charles B.; Velthuis Birgitta; Marquering Henk A.;
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正文语种 eng
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关键词
angiography; permeability; reperfusion; stroke; thrombosis;

机译：血管造影;通透性;再灌注;中风;血栓形成;

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1. Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke [J] . Santos Emilie M. M., Dankbaar Jan Willem, Treurniet Kilian M., Stroke: A Journal of Cerebral Circulation . 2016,第8期

机译：渗透性血栓与急性缺血性卒中患者较高的静脉重组组织型纤溶酶原激活剂治疗成功相关
2. Early Ischemic Change on CT Versus Diffusion-Weighted Imaging for Patients With Stroke Receiving Intravenous Recombinant Tissue-Type Plasminogen Activator Therapy: Stroke Acute Management With Urgent Risk-factor Assessment and Improvement (SAMURAI) rt-PA Registry. [J] . Nezu T, Koga M, Nakagawara J, Stroke: A Journal of Cerebral Circulation . 2011,第8期

机译：中风接受静脉重组组织型纤溶酶原激活剂治疗的中风患者的CT对比弥散加权成像的早期缺血性变化：中风急性病的急诊危险因素评估和改善（SAMURAI）rt-PA注册。
3. Recombinant Tissue-Type Plasminogen Activator Plus Eptifibatide Versus Recombinant Tissue-Type Plasminogen Activator Alone in Acute Ischemic Stroke Propensity Score-Matched Post Hoc Analysis [J] . Adeoye Opeolu, Sucharew Heidi, Khoury Jane, Stroke: A Journal of Cerebral Circulation . 2015,第2期

机译：重组组织型纤溶酶原激活物加依替巴肽与单独的急性缺血性卒中倾向得分匹配的重组组织型纤溶酶原激活物事后分析
4. The Changes of Tissue-Type Plasminogen Activator and Matrix Metalloproteinases in Neonatal Mice with Hypoxic-Ischemic Encephalopathy [C] . Xu JianWen, Wang Wei, Zhao XiaoZhen, International Conference on Mechanical Engineering and Intelligent Systems . 2012

机译：缺氧缺血性脑病新生小鼠组织型纤溶酶原激活剂和基质金属蛋白酶的变化
5. A structure-function analysis of the lysine-binding kringle 2 domains of human tissue-type plasminogen activator and human plasminogen by strategic mutagenesis. [D] . Nilsen, Stephanie Lynn. 1999

机译：通过战略诱变对人体组织型纤溶酶原激活物和纤溶酶原的赖氨酸结合kringle 2域的结构功能分析。
6. Intravenous tPA (Tissue-Type Plasminogen Activator) in Patients With Acute Ischemic Stroke Taking Non–Vitamin K Antagonist Oral Anticoagulants Preceding Stroke [O] . Chen Jin, Ryan J. Huang, Eric D. Peterson, -1

机译：急性缺血性中风患者在中风前服用非维生素K拮抗剂口服抗凝剂静脉tPA（组织型纤溶酶原激活物）
7. Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke [O] . Santos Emilie M. M., Dankbaar Jan Willem, Treurniet Kilian M., 2016

机译：渗透性血栓与急性缺血性卒中患者较高的静脉重组组织型纤溶酶原激活剂治疗成功相关

Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke

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