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Nanostructured polyaniline thin films as urea-sensing membranes in field-effect devices

机译：纳米结构聚苯胺薄膜作为场效应器件中的尿素传感膜

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摘要

We report the development of a urea biosensor based on a separative field-effect structure containing polyaniline in nanostructured form. Urea is normally produced by the nitrogen metabolism in the body, but its excess is indicative of kidney malfunction. Layer-by-layer (LbL) films of polyaniline in nanostructured form (N-PANI) and poly(vinylsulfonic acid) (PVS) were fabricated in a simple and low-cost way and used as pH-sensitive membranes. Urease was further immobilized on N-PANI by a reticulation process using glutaraldehyde (GA) as a crosslinking agent. The PVS/N-PANI-urease membrane was previously studied as a pH sensor using a junction field-effect transistor (JFET) input operational amplifier as a readout circuit and showed a Nernstian behaviour (~59 mV/pH) in the 6-8 pH range with a small voltage drift. The analytical curve of the biosensor showed a wide dynamic range of urea detection (0.05-10.0 mM), which covers the usual urea concentration in human blood, indicating that the proposed biosensor can be used in clinical analyses.
机译：我们报告了基于包含纳米结构形式的聚苯胺的分离场效应结构的尿素生物传感器的发展。尿素通常是由人体中的氮代谢产生的，但尿素过量则表明肾脏功能异常。纳米结构形式的聚苯胺（N-PANI）和聚（乙烯基磺酸）（PVS）的逐层（LbL）膜以简单且低成本的方式制成，并用作pH敏感膜。使用戊二醛（GA）作为交联剂，通过网状工艺将脲酶进一步固定在N-PANI上。先前曾研究过PVS / N-PANI-脲酶膜作为pH传感器，使用结型场效应晶体管（JFET）输入运算放大器作为读出电路，并且在6-8时显示能斯特行为（〜59 mV / pH） pH范围内电压漂移小。该生物传感器的分析曲线显示尿素检测的动态范围很广（0.05-10.0 mM），涵盖了人类血液中通常的尿素浓度，表明该生物传感器可用于临床分析。

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