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首页> 外文期刊>Critical reviews in microbiology >Autotransporter and two-partner secretion: delivery of large-size virulence factors by gram-negative bacterial pathogens.
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Autotransporter and two-partner secretion: delivery of large-size virulence factors by gram-negative bacterial pathogens.

机译：自转运蛋白和两伙伴分泌物：革兰氏阴性细菌病原体传递大毒力因子。

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摘要

A number of protein secretion mechanisms have been identified in gram-negative pathogens. Many of these secretion systems are dependent upon the Sec translocase for protein export from the cytoplasm into the periplasm and then utilize other mechanisms for transport from the periplasm through the outer membrane. In this article, we review secretion similarities between autotransporter and two-partner secretion systems, and we report similarities between the autotransporter secretion mechanism with that of intimin/invasins. Considering that many secreted proteins are virulence factors, a better understanding of their secretion mechanisms will aid in the development of disease treatments and new bacterial vaccines.
机译：在革兰氏阴性病原体中已经鉴定出许多蛋白质分泌机制。这些分泌系统中的许多依赖于Sec转位酶将蛋白质从细胞质输出到周质中，然后利用其他机制从周质通过外膜转运。在本文中，我们回顾了自转运蛋白和两伙伴分泌系统之间的分泌相似性，并报告了自转运蛋白与内膜素/侵袭素之间的相似性。考虑到许多分泌的蛋白质是毒力因子，对其分泌机制的更好理解将有助于疾病治疗和新细菌疫苗的开发。

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