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首页> 外文期刊>Physical chemistry chemical physics: PCCP >Phospholipid-based self-assembled mesophase systems for light-activated drug delivery
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Phospholipid-based self-assembled mesophase systems for light-activated drug delivery

机译：基于磷脂的自组装中间相系统，用于光激活药物递送

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The manipulation of the structure of phospholipid-based mesophases to induce a slow to fast drug release profile has potential for use in therapeutic situations where continuous absorption of drug is not desirable and reduce the frequency of injection for short acting or rapidly cleared drugs in treatments for diseases such as macular degeneration. This study had two aims; firstly to confirm the phase behaviour of 20 mol% cholesterol in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), which was previously reported to transition from lamellar (slow release) to bicontinuous cubic (fast release) phase with increasing temperature. Contrary to the literature, no bicontinuous cubic phase was observed but a transition to the inverse hexagonal phase occurred at all POPE : cholesterol ratios investigated. The second aim was to render these mesophases responsive to near-infrared laser (NIR) irradiation by incorporation of gold nanorods (GNR) incorporated into the POPE system to induce photothermal heating. The inclusion of 3 nM GNR in POPE systems induced reversible disruption of lipid packing equivalent to increasing the temperature to 55 degrees C when irradiated for 30 s. This study confirmed that although the previously published phase behavior was not correct, GNR and NIR can be used to manipulate the self-assembled mesophases in phospholipid-based systems and highlights the potential for a phospholipid-based light-activated drug delivery system.
机译：操纵基于磷脂的中间相的结构以诱导缓慢至快速的药物释放过程，可用于不希望连续吸收药物的治疗情况，并减少短效或快速清除药物的注射频率黄斑变性等疾病。这项研究有两个目的;首先要确认20 mol％胆固醇在1-棕榈酰基-2-油酰基-sn-甘油-3-磷酸乙醇胺（POPE）中的相行为，以前据报道它是从层状（缓慢释放）过渡到双连续立方（快速释放）相随着温度升高。与文献相反，未观察到双连续立方相，但在所有研究的POPE：胆固醇比率下均发生了向六方相的转变。第二个目标是通过将金纳米棒（GNR）掺入POPE系统中以诱导光热加热，使这些中间相对近红外激光（NIR）辐射产生响应。 POPE系统中包含3 nM GNR导致脂质堆积的可逆破坏，相当于在辐照30 s时将温度升至55摄氏度。这项研究证实，尽管先前公布的相行为不正确，但是GNR和NIR可以用于操纵基于磷脂的系统中的自组装中间相，并强调了基于磷脂的光活化药物输送系统的潜力。

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